Evidence map›Paper›PMID 24058000›Full record

ArticleInternational journal of epidemiology2014

Maternal pre-pregnancy body mass index and offspring attention deficit hyperactivity disorder: a population-based cohort study using a sibling-comparison design.

Qi Chen, Arvid Sjölander, Niklas Långström, Alina Rodriguez, Eva Serlachius, Brian M D'Onofrio, Paul Lichtenstein, Henrik Larsson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of epidemiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 8 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 8 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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  7. Maternal pre-pregnancy obesity and child neurodevelopmental outcomes: a meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2018
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  10. A Review of the Effects of Maternal and Paternal Obesity on Neurodevelopmental Disorders and Related Neurobiology in Rodent and Human Offspring.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Qi ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden, Department of Social Sciences-Psychology, Mid Sweden University, Östersund, Sweden, Department of Epidemiology and Biostatistics, Imperial College London, London, UK, Medical Research Council Social Genetic Developmental Psychiatry Centre, King's College London, London, UK, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden and Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA.
Arvid Sjölander
Niklas Långström
Alina Rodriguez
Eva Serlachius
Brian M D'Onofrio
Paul Lichtenstein
Henrik Larsson
Medical Research Council · GBIndiana University Bloomington · USKarolinska Institutet · SEKing's College London · GBMid Sweden University · SE

Funding

Quasi-experimental studies of early risk factors for severe psychopathologyR01HD061817 · NICHD · TRUSTEES OF INDIANA UNIVERSITY · PI D'ONOFRIO, BRIAN M, LICHTENSTEIN, PAUL · 2010 to 2013
$1.3M
NICHD NIH HHS HD061817
6 · The paper itself

Abstract

backgroundHigh maternal pre-pregnancy body mass index (BMI) is associated with increased risk of offspring attention deficit hyperactivity disorder (ADHD). However, the role of unmeasured familial confounding for this association remains unclear.

methodsWe conducted a population-based cohort study via linkage of Swedish national and regional registers to investigate maternal pre-pregnancy BMI (underweight: BMI <18.5; overweight: 25≤ BMI <30; obesity: BMI ≥30) in relation to offspring ADHD. We followed 673 632 individuals born in Sweden between 1992 and 2000, with prospectively collected information on maternal pre-pregnancy BMI, until they received an ADHD diagnosis or ADHD medication, death, emigration or 31 December 2009. Hazard ratios (HRs) were estimated by Cox proportional hazards models. Stratified Cox proportional hazards models were applied to data on full siblings to control for unmeasured familial confounding.

resultsAt the population level, pre-pregnancy overweight/obesity was associated with increased risk of offspring ADHD (HR(overweight) = 1.23, 95% CI = 1.18-1.27, P = 0.01; HR(obesity) = 1.64, 95% CI = 1.57-1.73, P = 0.01), after adjustment for measured covariates. In full sibling comparisons, however, previously observed associations no longer remained (HR(overweight) = 0.98, 95% CI = 0.83-1.16, P = 0.82; HR(obesity) = 1.15, 95% CI = 0.85-1.56, P = 0.38).

conclusionsThe results suggested that the association between maternal pre-pregnancy overweight/obesity and offspring ADHD could be ascribed to unmeasured familial confounding.

Indexed as

Body Mass IndexSiblingsAttention Deficit Disorder with HyperactivityFemaleFollow-Up StudiesHumansMaleMaternal BehaviorMother-Child RelationsMothersObesityPopulation SurveillancePregnancyProportional Hazards ModelsProspective StudiesRisk FactorsADHDconfoundingmaternal BMIprenatalsibling comparison

Identifiers

PMID24058000
PMCPMC3937971
OpenAlexW2158709600

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.