ReviewPsychopharmacology2014
Self-injurious behaviour in autistic children: a neuro-developmental theory of social and environmental isolation.
Review in Psychopharmacology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- Self-Injurious Behavior During Treatment of Pediatric Feeding Disorder: An Evaluation of Treatment Outcomes.Journal of autism and developmental disorders · 2026Article
- Non-Suicidal Self-Injury in Autism Spectrum Disorder: A Systematic Review of Associated Factors and Management Difficulties.Journal of clinical medicine · 2026Review
- From motion to emotion: exploring challenging behaviors in autism spectrum disorder through analysis of wearable physiology and movement.Physiological measurement · 2025Article
- Article
- Autism Spectrum Disorder: Focus on Glutamatergic Neurotransmission.International journal of molecular sciences · 2022Review
- The Current View on the Paradox of Pain in Autism Spectrum Disorders.Frontiers in psychiatry · 2022Review
- Management of Self-injurious Behaviors in Children with Neurodevelopmental Disorders: A Pharmacotherapy Overview.Pharmacotherapy · 2019Review
- Ethical Implications for Providers Regarding Cannabis Use in Children With Autism Spectrum Disorders.Pediatrics · 2019Article
- Self-injurious behaviors in children with autism spectrum disorder enrolled in the Study to Explore Early Development.Autism : the international journal of research and practice · 2018Article
- Corticosterone Signaling and a Lateral Habenula-Ventral Tegmental Area Circuit Modulate Compulsive Self-Injurious Behavior in a Rat Model.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Factors Associated with Self-Injurious Behaviors in Children with Autism Spectrum Disorder: Findings from Two Large National Samples.Journal of autism and developmental disorders · 2017Article
- Brief Report: Prevalence of Self-injurious Behaviors among Children with Autism Spectrum Disorder-A Population-Based Study.Journal of autism and developmental disorders · 2016Article
- Repetitive Behavior in Neurodevelopmental Disorders: Clinical and Translational Findings.The Behavior analyst · 2015Article
- Autism spectrum disorders--an emerging area in psychopharmacology.Psychopharmacology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleSelf-injurious behaviour is not one of the three core symptoms that define autism. However, children on the autism spectrum appear to be particularly vulnerable. Afflicted children typically slap their faces, punch or bang their heads, and bite or pinch themselves. These behaviours can be extremely destructive, and they interfere with normal social and educational activities. However, the neurobiological mechanisms that confer vulnerability in children with autism have not been adequately described.
objectivesThis review explores behavioural and neurobiological characteristics of children with autism that may be relevant for an increased understanding of their vulnerability for self-injurious behaviour.
methodsBehavioural characteristics that are co-morbid for self-injurious behaviour in children with autism are examined. In addition, the contributions of social and environmental deprivation in self-injurious institutionalized orphans, isolated rhesus macaques, and additional animal models are reviewed.
resultsThere is extensive evidence that social and environmental deprivation promotes self-injurious behaviour in both humans (including children with autism) and animal models. Moreover, there are multiple lines of convergent neuroanatomical, neurophysiological, and neurochemical data that draw parallels between self-injurious children with autism and environmentally deprived humans and animals.
conclusionsA hypothesis is presented that describes how the core symptoms of autism make these children particularly vulnerable for self-injurious behaviour. Relevant neurodevelopmental pathology is described in cortical, limbic, and basal ganglia brain regions, and additional research is suggested.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.