ReviewProtein & cell2013
GPCR activation: protonation and membrane potential.
Review in Protein & cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Suspendable and Scalable Ultrasound-Actuated ZnO-Nanosheet-Based Piezoelectric Microdevices for Wireless Electrical Stimulation of Cells.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Structural and dynamic insights into agonist recognition and function of the thromboxane ANature communications · 2026Article
- Effects of pH on opioid receptor activation and implications for drug design.Biophysical journal · 2024Review
- pJournal of chemical information and modeling · 2024Article
- Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists.The EMBO journal · 2023Article
- G Protein-Coupled Receptors Regulated by Membrane Potential.International journal of molecular sciences · 2022Review
- The Many Faces of G Protein-Coupled Receptor 143, an Atypical Intracellular Receptor.Frontiers in molecular biosciences · 2022Review
- Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions.PLoS computational biology · 2020Article
- Proton Sensitivity of Corticotropin-Releasing Hormone Receptor 1 Signaling to Proopiomelanocortin in Male Mice.Endocrinology · 2019Article
- A Novel Voltage Sensor in the Orthosteric Binding Site of the M2 Muscarinic Receptor.Biophysical journal · 2016Article
- Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors.Structure (London, England : 1993) · 2016Article
- Energy coupling mechanisms of MFS transporters.Protein science : a publication of the Protein Society · 2015Review
- Identification of Distinct Conformations of the Angiotensin-II Type 1 Receptor Associated with the Gq/11 Protein Pathway and the β-Arrestin Pathway Using Molecular Dynamics Simulations.The Journal of biological chemistry · 2015Article
- Proton transfer-mediated GPCR activation.Protein & cell · 2015Review
- Why is dimerization essential for class-C GPCR function? New insights from mGluR1 crystal structure analysis.Protein & cell · 2014Article
- Thermodynamics of GPCR activation.Biophysics reportsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GPCR proteins represent the largest family of signaling membrane proteins in eukaryotic cells. Their importance to basic cell biology, human diseases, and pharmaceutical interventions is well established. Many crystal structures of GPCR proteins have been reported in both active and inactive conformations. These data indicate that agonist binding alone is not sufficient to trigger the conformational change of GPCRs necessary for binding of downstream G-proteins, yet other essential factors remain elusive. Based on analysis of available GPCR crystal structures, we identified a potential conformational switch around the conserved Asp2.50, which consistently shows distinct conformations between inactive and active states. Combining the structural information with the current literature, we propose an energy-coupling mechanism, in which the interaction between a charge change of the GPCR protein and the membrane potential of the living cell plays a key role for GPCR activation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.