ArticleNucleic acids research2014
MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
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- Identification of novel high-risk genes in gastric cancer through single-cell RNA sequencing, eQTL Mendelian randomization, and in vitro validation.Global medical genetics · 2025Article
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- The Role of miR-138 in Cardiovascular Diseases.BioMed research international · 2025Review
- Oral cancer cell to endothelial cell communication via exosomal miR-21/RMND5A pathway.BMC oral health · 2024Article
- The microRNA Lifecycle in Health and Cancer.Cancers · 2022Review
- Mesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-β/Smad pathway.Bioengineered · 2021Article
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- Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy.Bioengineered · 2021Article
- miR-590-5p targets RMND5A and promotes migration in pancreatic adenocarcinoma cell lines.Oncology letters · 2021Article
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- MicroRNA-30c-2-3p regulates ER stress and induces apoptosis in ovarian cancer cells underlying ER stress.EXCLI journal · 2021Article
- Down-regulation of microRNA-138 improves immunologic function via negatively targeting p53 by regulating liver macrophage in mice with acute liver failure.Bioscience reports · 2019Article
- Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche.Leukemia · 2018Article
- The Role of Exportin-5 in MicroRNA Biogenesis and Cancer.Genomics, proteomics & bioinformatics · 2018Review
- An alternative microRNA-mediated post-transcriptional regulation of GADD45A by p53 in human non-small-cell lung cancer cells.Scientific reports · 2017Article
- Cell signalling pathway regulation by RanBPM: molecular insights and disease implications.Open biology · 2017Review
- HCV core inhibits hepatocellular carcinoma cell replicative senescence through downregulating microRNA-138 expression.Journal of molecular medicine (Berlin, Germany) · 2017Article
- MicroRNA-138 inhibits proliferation, migration and invasion through targeting hTERT in cervical cancer.Oncology letters · 2016Article
- Species-specific mutual regulation of p53 and miR-138 between human, rat and mouse.Scientific reports · 2016Article
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) are a class of non-coding small RNAs that consist of ≈ 22 nt and are involved in several biological processes by regulating target gene expression. MiR-138 has many biological functions and is often downregulated in cancers. Our results showed that overexpression of miR-138 downregulated target RMND5A (required for meiotic nuclear division 5 homolog A) and reduced Exportin-5 stability, which results in decreased levels of pre-miRNA nuclear export in HeLa cells. We also found that miR-138 could significantly inhibit HeLa cell migration by targeting RMND5A. Our study therefore identifies miR-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells.
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