Evidence map›Paper›PMID 24057131›Full record

SynthesisJournal of autism and developmental disorders2014

Maternal diabetes and the risk of autism spectrum disorders in the offspring: a systematic review and meta-analysis.

Guifeng Xu, Jin Jing, Katherine Bowers, Buyun Liu, Wei Bao

Open access · greenAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of autism and developmental disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
96citing papers in PubMed, 12 pooled it
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

96 citing papers in PubMed, 12 syntheses or guidelines pooled it, 197 citations in OpenAlex.

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  8. The Prevalence of Diabetes in Autistic Persons: A Systematic Review.Clinical practice and epidemiology in mental health : CP & EMH · 2020
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36 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Guifeng XuDepartment of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China.
Jin Jing
Katherine Bowers
Buyun Liu
Wei Bao
Sun Yat-sen University · CNEunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Cincinnati · US

Funding

Intramural NIH HHS Z99 HD999999
6 · The paper itself

Abstract

We performed a systematic literature search regarding maternal diabetes before and during pregnancy and the risk of autism spectrum disorders (ASD) in the offspring. Of the 178 potentially relevant articles, 12 articles including three cohort studies and nine case-control studies were included in the meta-analysis. Both the meta-analyses of cohort studies and case-control studies showed significant associations. The pooled relative risk and 95% confidence interval (CI) among cohort studies was 1.48 (1.25-1.75, p < 0.001). For case-control studies, the pooled odds ratio and 95% CI was 1.72 (1.24-2.41, p = 0.001). No indication of significant heterogeneity across studies or publication bias was observed. In conclusion, maternal diabetes was significantly associated with a greater risk of ASD in the offspring.

Indexed as

Diabetes, GestationalPregnancy in DiabeticsChildChild Development Disorders, PervasiveDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansPregnancyRisk

Identifiers

PMID24057131
PMCPMC4181720
OpenAlexW2080896782

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.