ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2014
Diagnostic accuracy of lipopolysaccharide-binding protein for predicting bacteremia/clinical sepsis in children with febrile neutropenia: comparison with interleukin-6, procalcitonin, and C-reactive protein.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Biomarkers for Diagnosing Febrile Illness in Immunocompromised Children: A Systematic Review of the Literature.Frontiers in pediatrics · 2022Pooled it
- Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis.BMC infectious diseases · 2019Pooled it
- Role of biomarkers in pediatric sepsis: What evidence says?World journal of clinical pediatrics · 2026Review
- CD48 as a Novel Early Biomarker Complementing Procalcitonin and Lactate for Predicting Bacteremia in Pediatric Febrile Neutropenia: A Prospective Cohort Study.Mediterranean journal of hematology and infectious diseases · 2026Article
- Prognostic role of mid-regional pro-adrenomedullin in predicting infection in pediatric cancer with febrile neutropenia.Clinical and experimental pediatrics · 2025Article
- Assessment value of interleukin-6, procalcitonin, and C-reactive protein early kinetics for initial antibiotic efficacy in patients with febrile neutropenia: A prospective study.Cancer medicine · 2024Article
- Machine Learning Approach to Predicting Absence of Serious Bacterial Infection at PICU Admission.Hospital pediatrics · 2022Article
- The clinical outcomes and biomarker features of severe sepsis/septic shock with severe neutropenia: a retrospective cohort study.Translational pediatrics · 2021Article
- Biomarkers of sepsis: time for a reappraisal.Critical care (London, England) · 2020Review
- Prognostic value of procalcitonin and lipopolysaccharide binding protein in cancer patients with chemotherapy-associated febrile neutropenia presenting to an emergency department.Biochemia medica · 2019Observational
- Predictive value of PCT and IL-6 for bacterial infection in children with cancer and febrile neutropenia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Presepsin as a diagnostic marker of bacterial infections in febrile neutropenic pediatric patients with hematological malignancies.International journal of hematology · 2018Article
- An Eye on Age-Related Macular Degeneration: The Role of MicroRNAs in Disease Pathology.Molecular diagnosis & therapy · 2017Review
- AME evidence series 001-The Society for Translational Medicine: clinical practice guidelines for diagnosis and early identification of sepsis in the hospital.Journal of thoracic disease · 2016Review
- Value of lipopolysaccharide binding protein as diagnostic marker of infection in adult cancer patients with febrile neutropenia: comparison with C-reactive protein, procalcitonin, and interleukin 6.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Clinical potential of resistin as a novel prognostic biomarker for cellulitis.Experimental and therapeutic medicine · 2015Article
- C-reactive protein and the MASCC risk index identify high-risk patients with febrile neutropenia and hematologic neoplasms.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2015Article
- Markers for sepsis diagnosis in the forensic setting: state of the art.Croatian medical journal · 2014Review
- Use of biomarkers in pediatric sepsis: literature review.Revista Brasileira de terapia intensivaReview
- Bloodstream infection in pediatric patients with febrile neutropenia induced by chemotherapy.Hematology, transfusion and cell therapyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn febrile neutropenia (FN), no reliable marker has been identified to discriminate between severe infection and other causes of fever early in the clinical course. Since lipopolysaccharide-binding protein (LBP) has proven to be an accurate biomarker of bacteremia/clinical sepsis in critically ill non-immunocompromised infants and children, we performed a prospective study to determine the diagnostic accuracy of LBP in children with FN.
methodsConcentrations of LBP, procalcitonin (PCT), interleukin-6 (IL-6), and C-reactive protein (CRP) were prospectively measured on two consecutive days in 90 FN episodes experienced by 47 children. Receiver operating characteristic curve analysis was performed for each biomarker to predict bacteremia/clinical sepsis and severe sepsis.
resultsEighteen of the 90 episodes were classified as bacteremia/clinical sepsis. On both days 1 and 2, all biomarkers had a low to intermediate diagnostic accuracy for sepsis, and no significant differences were found between them (area under the curve (AUC) for LBP, 0.648 and 0.714; for PCT, 0.665 and 0.744; for IL-6, 0.775 and 0.775; and for CRP, 0.695 and 0.828). Comparison of their AUCs to the AUC of maximum body temperature on admission (AUC = 0.668) also failed to show any significant differences. In severe sepsis, however, the best diagnostic accuracies were found for IL-6 and PCT (AUC 0.892 and 0.752, respectively), and these were significantly higher than those for LBP (AUC 0.566) on admission.
conclusionsOn admission and 24 h later, the LBP concentration is less accurate for predicting bacteremia/clinical sepsis compared to IL-6, PCT, and CRP.
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