ArticleNanoscale2013
Single-cell force spectroscopy of the medically important Staphylococcus epidermidis-Candida albicans interaction.
Article in Nanoscale, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 89 citations in OpenAlex.
- Advances in scanning probe microscopy for biological systems.Biophysics reports · 2026Article
- Host soluble plasma factors increase dual-species Staphylococcus epidermidis and Candida albicans biofilm biomass without enhancing stress tolerance.Scientific reports · 2026Article
- Single-Cell Force Spectroscopy Uncovers Root Zone- and Bacteria-Specific Interactions.Angewandte Chemie (International ed. in English) · 2025Article
- Nanomechanical characterization of soft nanomaterial using atomic force microscopy.Materials today. Bio · 2025Review
- Efficacy and mechanism ofFrontiers in cellular and infection microbiology · 2023Article
- In it together: Candida-bacterial oral biofilms and therapeutic strategies.Environmental microbiology reports · 2022Review
- Interactions betweenFrontiers in microbiology · 2022Review
- The Role of the Oral Immune System in Oropharyngeal Candidiasis-Facilitated Invasion and Dissemination ofFrontiers in oral health · 2022Review
- Using Knock-Out Mutants to Investigate the Adhesion ofInternational journal of molecular sciences · 2021Article
- Nutrient Deficiency Promotes the Entry ofBiology · 2021Article
- Pili and other surface proteins influence the structure and the nanomechanical properties of Lactococcus lactis biofilms.Scientific reports · 2021Article
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- Recent Advances in Presentation, Diagnosis and Treatment for Mixed Vaginitis.Frontiers in cellular and infection microbiology · 2021Review
- Metabolic Adaptations DuringFrontiers in immunology · 2021Review
- Article
- Let's Get Physical: Bacterial-Fungal Interactions and Their Consequences in Agriculture and Health.Journal of fungi (Basel, Switzerland) · 2020Review
- Atomic Force Microscopy (AFM) As a Surface Mapping Tool in Microorganisms Resistant Toward Antimicrobials: A Mini-Review.Frontiers in pharmacology · 2020Review
- Adhesion ofFrontiers in cellular and infection microbiology · 2020Article
- Microbial adhesion and ultrastructure from the single-molecule to the single-cell levels by Atomic Force Microscopy.Cell surface (Amsterdam, Netherlands) · 2019Review
- Fluidic Force Microscopy Demonstrates That Homophilic Adhesion by Candida albicans Als Proteins Is Mediated by Amyloid Bonds between Cells.Nano letters · 2019Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite the clinical importance of bacterial-fungal interactions, their molecular details are poorly understood. A hallmark of such medically important interspecies associations is the interaction between the two nosocomial pathogens Staphylococcus aureus and Candida albicans, which can lead to mixed biofilm-associated infections with enhanced antibiotic resistance. Here, we use single-cell force spectroscopy (SCFS) to quantify the forces engaged in bacterial-fungal co-adhesion, focusing on the poorly investigated S. epidermidis-C. albicans interaction. Force curves recorded between single bacterial and fungal germ tubes showed large adhesion forces (~5 nN) with extended rupture lengths (up to 500 nm). By contrast, bacteria poorly adhered to yeast cells, emphasizing the important role of the yeast-to-hyphae transition in mediating adhesion to bacterial cells. Analysis of mutant strains altered in cell wall composition allowed us to distinguish the main fungal components involved in adhesion, i.e. Als proteins and O-mannosylations. We suggest that the measured co-adhesion forces are involved in the formation of mixed biofilms, thus possibly as well in promoting polymicrobial infections. In the future, we anticipate that this SCFS platform will be used in nanomedicine to decipher the molecular mechanisms of a wide variety of pathogen-pathogen interactions and may help in designing novel anti-adhesion agents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.