ArticleNature methods2013
Inducible control of gene expression with destabilized Cre.
Article in Nature methods, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 113 citations in OpenAlex.
- CellCousin2: an optimized system for partial ablation and tracing of regenerative lineages.NPJ Regenerative medicine · 2026Article
- A chemically inducible, leakless Cre recombinase by split-protein-based efficient and enhanced degradation (SPEED).Communications biology · 2025Article
- Synaptic potentiation of engram cells is necessary and sufficient for context fear memory.Communications biology · 2025Article
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- Synaptic architecture of a memory engram in the mouse hippocampus.Science (New York, N.Y.) · 2025Article
- Delivering large genes using adeno-associated virus and the CRE-lox DNA recombination system.Human molecular genetics · 2024Article
- An Approach to Intersectionally Target Mature Enteroendocrine Cells in the Small Intestine of Mice.Cells · 2024Article
- Defining Gene Function in Spermatogonial Stem Cells Through Conditional Knockout Approaches.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Mouse models of diffuse large B cell lymphoma.Frontiers in immunology · 2023Review
- Selective Menin Deletion in the Hippocampal CA1 Region Leads to Disruption of Contextual Memory in theCells · 2022Article
- Stable Transgenic Mouse Strain with Enhanced Photoactivatable Cre Recombinase for Spatiotemporal Genome Manipulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Development and transdifferentiation into inner hair cells require Tbx2.National science review · 2022Article
- Chronic CaeLife · 2022Article
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- Transgenic mice encoding modern imaging probes: Properties and applications.Cell reports · 2022Review
- A Genetic Toolkit for Simultaneous Generation ofNeuroscience insights · 2022Article
- Engineering living therapeutics with synthetic biology.Nature reviews. Drug discovery · 2021Review
- RB depletion is required for the continuous growth of tumors initiated by loss of RB.PLoS genetics · 2021Article
- A genetically targeted reporter for PET imaging of deep neuronal circuits in mammalian brains.The EMBO journal · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Acute manipulation of gene and protein function in the brain is essential for understanding the mechanisms of nervous system development, plasticity and information processing. Here we describe a technique based on a destabilized Cre recombinase (DD-Cre) whose activity is controlled by the antibiotic trimethoprim (TMP). We show that DD-Cre triggers rapid TMP-dependent recombination of loxP-flanked ('floxed') alleles in mouse neurons in vivo and validate the use of this system for neurobehavioral research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.