ArticleLab on a chip2013
Nanotextured superhydrophobic electrodes enable detection of attomolar-scale DNA concentration within a droplet by non-faradaic impedance spectroscopy.
Article in Lab on a chip, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 84 citations in OpenAlex.
- Interfacial and Bulk Properties of Volatile Amphiphiles and Sodium Dodecyl Sulfate Mixtures.Molecules (Basel, Switzerland) · 2026Article
- Selective Wettability-Driven Evaporation-Enhanced Redox Cycling for Robust and Ultrasensitive Detection of Viral Particles.Small methods · 2026Article
- Evaporation-Enhanced Redox Cycling for Rapid Detection of Attomolar SARS-CoV-2 Virions Using Nanolithography-Free Electrochemical Devices.Advanced materials technologies · 2025Article
- Electrode Droplet Microarray (eDMA): An Impedance Platform for Label-Free Parallel Monitoring of Cellular Drug Response in Nanoliter Droplets.Advanced healthcare materials · 2025Article
- Understanding dynamic voltammetry in a dissolving microdroplet.The Analyst · 2024Article
- Recent advances in graphene-based electroanalytical devices for healthcare applications.Nanoscale · 2024Review
- Non-Faradaic Impedimetric Detection of Heavy Metal Ions via a Hybrid Nanoparticle-DNAzyme Biosensor.Biosensors · 2024Article
- Durable superhydrophobic surface in wearable sensors: From nature to application.Exploration (Beijing, China) · 2024Review
- Advances in field-effect biosensors towards point-of-use.Nanotechnology · 2023Review
- Suppression of wetting transition on evaporative fakir droplets by using slippery superhydrophobic surfaces with low depinning force.Scientific reports · 2023Article
- Rapid and sensitive detection of viral particles by coupling redox cycling and electrophoretic enrichment.Biosensors & bioelectronics · 2022Article
- Bioinspired superwettable electrodes towards electrochemical biosensing.Chemical science · 2022Review
- Micro/Nanopatterned Superhydrophobic Surfaces Fabrication for Biomolecules and Biomaterials Manipulation and Analysis.Micromachines · 2021Review
- Analyzing Thermal Stability of Cell Membrane of Salmonella Using Time-Multiplexed Impedance Sensing.Biophysical journal · 2018Article
- Highly Sensitive and Practical Detection of Plant Viruses via Electrical Impedance of Droplets on Textured Silicon-Based Devices.Sensors (Basel, Switzerland) · 2016Article
- Ultrasensitive, Label Free, Chemiresistive Nanobiosensor Using Multiwalled Carbon Nanotubes Embedded Electrospun SU-8 Nanofibers.Sensors (Basel, Switzerland) · 2016Article
- Evaporation-induced stimulation of bacterial osmoregulation for electrical assessment of cell viability.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Review
- Water and Ethanol Droplet Wetting Transition during Evaporation on Omniphobic Surfaces.Scientific reports · 2015Article
- Nano-guided cell networks as conveyors of molecular communication.Nature communications · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Label-free, rapid detection of biomolecules in microliter volumes of highly diluted solutions (sub-femtomolar) is of essential importance for numerous applications in medical diagnostics, food safety, and chem-bio sensing for homeland security. At ultra-low concentrations, regardless of the sensitivity of the detection approach, the sensor response time is limited by physical diffusion of molecules towards the sensor surface. We have developed a fast, low cost, non-faradaic impedance sensing method for detection of synthetic DNA molecules in DI water at attomolar levels by beating the diffusion limit through evaporation of a micro-liter droplet of DNA on a nanotextured superhydrophobic electrode array. Continuous monitoring of the impedance of individual droplets as a function of evaporation time is exploited to dramatically improve the sensitivity and robustness of detection. Formation of the nanostructures on the electrode surface not only increases the surface hydrophobicity, but also allows robust pinning of the droplet contact area to the sensor surface. These two features are critical for performing highly stable impedance measurements as the droplet evaporates. Using this scheme, the detection limit of conventional non-faradaic methods is improved by five orders of magnitude. The proposed platform represents a step-forward towards realization of ultra-sensitive lab-on-chip biomolecule detectors for real time point-of-care application. Further works are however needed to ultimately realize the full potential of the proposed approach to appraise biological samples in complex buffer solutions rather than in DI water.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.