ReviewThe Indian journal of medical research2013
New approaches & technologies of venomics to meet the challenge of human envenoming by snakebites in India.
Review in The Indian journal of medical research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed.
- Mortality due to snakebite and other venomous animals in the Indian state of Bihar: Findings from a representative mortality study.PloS one · 2018Trial
- Clinicopathological Features, Management, and Outcomes of Zebra Spitting Cobra (Naja nigricincta nigricincta) and Puff Adder (Bitis arietans) Snakebites in Namibia.BioMed research international · 2026Observational
- Preclinical evaluation of small molecule inhibitors as early intervention therapeutics against Russell's viper envenoming in India.Communications medicine · 2025Article
- Article
- The geographical distribution of scorpions, implication of venom toxins, envenomation, and potential therapeutics in Southern and Northern Africa.Toxicology research · 2024Review
- Knowledge and perceptions of snakes, snakebites and their management among health care workers in Sudan.PloS one · 2024Article
- Review
- Multilevel Comparison of IndianToxins · 2023Article
- Evaluation of the properties ofToxicon: X · 2023Article
- Inhibitory Effects of Varespladib, CP471474, and Their Potential Synergistic Activity onMolecules (Basel, Switzerland) · 2022Article
- The Middle Eastern Cousin: Comparative Venomics ofToxins · 2022Article
- The Preclinical Evaluation of a Second-Generation Antivenom for Treating Snake Envenoming in India.Toxins · 2022Article
- A simple mortality risk prediction score for viper envenoming in India (VENOMS): A model development and validation study.PLoS neglected tropical diseases · 2022Article
- Cytotoxin antibody-based colourimetric sensor for field-level differential detection of elapid among big four snake venom.PLoS neglected tropical diseases · 2021Article
- Hemothorax after snake bite.Clinical case reports · 2021Article
- Biogeographic venom variation in Russell's viper (Daboia russelii) and the preclinical inefficacy of antivenom therapy in snakebite hotspots.PLoS neglected tropical diseases · 2021Article
- Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy.PLoS neglected tropical diseases · 2021Article
- Article
- A Neurotoxic Snake Venom without Phospholipase AToxins · 2021Article
- Crowdsourcing snake identification with online communities of professional herpetologists and avocational snake enthusiasts.Royal Society open science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The direct estimate of 46,000 snakebite deaths in India in 2005 (1 for every 2 HIV/AIDS deaths), based on verbal autopsies, renders unrealistic the total of only 47,000 snakebite deaths in the whole world in 2010, obtained indirectly as part of the "Global Burden of Disease 2010" study. Persistent underestimation of its true morbidity and mortality has made snakebite the most neglected of all the WHO's "neglected tropical diseases", downgrading its public health importance. Strategies to address this neglect should include the improvement of antivenom, the only specific antidote to envenoming. To accommodate increased understanding of geographical intraspecific variation in venom composition and the range of snake species that are medically important in India, the design of antivenoms (choice of venom sources and species coverage) should be reconsidered. Methods of preclinical and clinical testing should be improved. The relatively new science of venomics involves techniques and strategies for assessing the toxin composition of snake venoms directly through proteomics-centred approaches or indirectly via high-throughput venom gland transcriptomics and bioinformatic analysis. Antivenomics is translational venomics: a proteomics-based protocol to quantify the extent of cross-reactivity of antivenoms against homologous and heterologous venoms. These approaches could revolutionize the preclinical assessment of antivenom efficacy, leading to a new generation of antivenoms that are clinically more effective.
Indexed as
Identifiers
24056555PMC3767246What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.