ArticleBMJ open2013
Asthma related to cleaning agents: a clinical insight.
Article in BMJ open, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A systematic review of the relation between ten potential occupational sensitizing exposures and asthma.Scandinavian journal of work, environment & health · 2025Pooled it
- Airway inflammatory profile among cleaning workers from different workplaces.BMC pulmonary medicine · 2022Trial
- Quaternary Ammonium Compounds: A Chemical Class of Emerging Concern.Environmental science & technology · 2023Review
- Characterization of Cleaning and Disinfection Product Use, Glove Use, and Skin Disorders by Healthcare Occupations in a Midwestern Healthcare Facility.Buildings (Basel, Switzerland) · 2022Article
- Disinfection in the time of COVID: Safe solutions are critical for schools.Paediatrics & child health · 2022Article
- Prevalence and predictors of occupational asthma among workers in detergent and cleaning products industry and its impact on quality of life in El Asher Men Ramadan, Egypt.Environmental science and pollution research international · 2022Article
- Quaternary ammonium compounds in hypersensitivity reactions.Frontiers in toxicology · 2022Review
- Benzalkonium Chloride Disinfectants Induce Apoptosis, Inhibit Proliferation, and Activate the Integrated Stress Response in a 3-DChemical research in toxicology · 2021Article
- Inhalation Challenge Tests in Occupational Asthma: Why Are Multiple Tests Needed?Turkish thoracic journal · 2021Review
- Prior Exposure to Ortho-Phthalaldehyde Augments IgE-Mediated Immune Responses to Didecyldimethylammonium Chloride: Potential for 2 Commonly Used Antimicrobials to Synergistically Enhance Allergic Disease.Toxicological sciences : an official journal of the Society of Toxicology · 2020Article
- Asthma associated with denatonium benzoate in a healthcare worker in Taiwan: A case report.Medicine · 2019Article
- Topical Application of the Quaternary Ammonium Compound Didecyldimethylammonium Chloride Activates Type 2 Innate Lymphoid Cells and Initiates a Mixed-Type Allergic Response.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Methodological evaluation of human research on asthmagenicity and occupational cleaning: a case study of quaternary ammonium compounds ("quats").Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2019Review
- Opportunities and obstacles in translating evidence to policy in occupational asthma.Annals of epidemiology · 2018Article
- Health risks in the cleaning industry: a Belgian census-linked mortality study (1991-2011).International archives of occupational and environmental health · 2018Article
- Chemical-induced asthma and the role of clinical, toxicological, exposure and epidemiological research in regulatory and hazard characterization approaches.Regulatory toxicology and pharmacology : RTP · 2017Article
- An Official American Thoracic Society Workshop Report: Presentations and Discussion of the Sixth Jack Pepys Workshop on Asthma in the Workplace.Annals of the American Thoracic Society · 2017Article
- Biomarkers in Occupational Asthma.Current allergy and asthma reports · 2016Review
- Traditional and environmentally preferable cleaning product exposure and health symptoms in custodians.American journal of industrial medicine · 2015Article
- An official American Thoracic Society Workshop Report: presentations and discussion of the fifth Jack Pepys Workshop on Asthma in the Workplace. Comparisons between asthma in the workplace and non-work-related asthma.Annals of the American Thoracic Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the agents causing asthmatic reactions during specific inhalation challenges (SICs) in workers with cleaning-related asthma symptoms and to assess the pattern of bronchial responses in order to identify the mechanisms involved in cleaning-related asthma.
designA retrospective case series analysis.
settingThe study included all participants who completed an SIC procedure with the cleaning/disinfection products suspected of causing work-related asthma over the period 1992-2011 in a tertiary centre, which is the single specialised centre of the French-speaking part of Belgium where all participants with work-related asthma are referred to for SIC.
resultsThe review identified 44 participants who completed an SIC with cleaning/disinfection agents. Challenge exposure to the suspected cleaning agents elicited a ≥20% fall in forced expiratory volume in 1 s (FEV1) in 17 (39%) participants. The cleaning products that induced a positive SIC contained quaternary ammonium compounds (n=10), glutaraldehyde (n=3), both of these agents (n=1) and ethanolamines (n=2). Positive SICs were associated with a significant decrease in the median (IQR) value of the provocative concentration of histamine causing a 20% fall in FEV1 (PC20) from 1.4 (0.2-4.2) mg/mL at baseline to 0.5 (0.4-3.0) mg/mL after the challenge and a significant increase in sputum eosinophils from 1.8 (0.8-7.2)% at baseline to 10.0 (4.1-15.9)% 7 h after the challenge exposure while these parameters did not significantly change in participants with a negative SIC. Overall, 11 of 17 participants with positive SICs showed greater than threefold decrease in postchallenge histamine PC20 value, a >2% increase in sputum eosinophils, or both of these outcomes.
conclusionsThese data indicate that a substantial proportion of workers who experience asthma symptoms related to cleaning materials show a pattern of bronchial reaction consistent with sensitiser-induced occupational asthma. The results also suggest that quaternary ammonium compounds are the principal cause of sensitiser-induced occupational asthma among cleaners.
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Registered trials
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