ArticleApplied and environmental microbiology2013
Early and late trisporoids differentially regulate β-carotene production and gene transcript Levels in the mucoralean fungi Blakeslea trispora and Mucor mucedo.
Article in Applied and environmental microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Evolutionary adaptation of CCD4 enzymes inFrontiers in plant science · 2026Article
- Production of Fungal Pigments: Molecular Processes and Their Applications.Journal of fungi (Basel, Switzerland) · 2022Review
- SR5AL serves as a key regulatory gene in lycopene biosynthesis by Blakeslea trispora.Microbial cell factories · 2022Article
- Mucoromycota fungi as powerful cell factories for modern biorefinery.Applied microbiology and biotechnology · 2022Review
- Terpenoid Biosynthesis Dominates among Secondary Metabolite Clusters inJournal of fungi (Basel, Switzerland) · 2021Article
- Bacterial-Like Nonribosomal Peptide Synthetases Produce Cyclopeptides in the Zygomycetous Fungus Mortierella alpina.Applied and environmental microbiology · 2021Article
- Emerging Roles of Carotenoids in the Survival and Adaptations of Microbes.Indian journal of microbiology · 2019Article
- Fungal Sex: The Mucoromycota.Microbiology spectrum · 2017Review
- Biological roles of fungal carotenoids.Current genetics · 2015Review
- Sex in the Mucoralean fungi.Mycoses · 2014Review
- Easy access to a cyclic key intermediate for the synthesis of trisporic acids and related compounds.Molecules (Basel, Switzerland) · 2014Article
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The multistep cleavage of carotenoids in Mucorales during the sexual phase results in a cocktail of trisporic acid (C18) sex pheromones. We hypothesized that the C18 trisporoid intermediates have a specific regulatory function for sex pheromone production and carotenogenesis that varies with genus/species and vegetative and sexual phases of their life cycles. Real-time quantitative PCR kinetics determined for Blakeslea trispora displayed a very high transcript turnover in the gene for carotenoid cleavage dioxygenase, tsp3, during the sexual phase. An in vivo enzyme assay and chromatographic analysis led to the identification of β-apo-12'-carotenal as the first apocarotenoid involved in trisporic acid biosynthesis in B. trispora. Supplementation of C18 trisporoids, namely D'orenone, methyl trisporate C, and trisporin C, increased tsp3 transcripts in the plus compared to minus partners. Interestingly, the tsp1 gene, which is involved in trisporic acid biosynthesis, was downregulated compared to tsp3 irrespective of asexual or sexual phase. Only the minus partners of both B. trispora and Mucor mucedo had enhanced β-carotene production after treatment with C20 apocarotenoids, 15 different trisporoids, and their analogues. We conclude that the apocarotenoids and trisporoids influence gene transcription and metabolite production, depending upon the fungal strain, corresponding genus, and developmental phase, representing a "chemical dialect" during sexual communication.
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