ArticleNature chemistry2013
End-to-end conformational communication through a synthetic purinergic receptor by ligand-induced helicity switching.
Article in Nature chemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 121 citations in OpenAlex.
- Aromatic Amide Foldamers Show Conformation-Dependent Electronic Properties.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Mechanisms of Chiral Induction to Foldamer Backbones.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Stimulus-Induced Relief of Intentionally Incorporated Frustration Drives Refolding of a Water-Soluble Biomimetic Foldamer.Journal of the American Chemical Society · 2023Article
- Anion-Dependent Hydrogen-Bond Polarity Switching in Ethylene-bridged Urea Oligomers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Chemically Fueled Communication Along a Scaffolded Nanoscale Array of Squaramides.Angewandte Chemie (International ed. in English) · 2023Article
- Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction.Nature communications · 2023Article
- Switching imidazole reactivity by dynamic control of tautomer state in an allosteric foldamer.Nature communications · 2023Article
- Screw sense and screw sensibility: communicating information by conformational switching in helical oligomers.Chemical Society reviews · 2023Review
- A ChiralJournal of the American Chemical Society · 2022Article
- An Orthogonal Dynamic Covalent Chemistry Tool for Ring-Opening Polymerization of Cyclic Oligochalcogenides on Detachable Helical Peptide Templates.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Inducing a pH-dependent conformational response by competitive binding to ZnChemical science · 2022Article
- α-Amino-iso-Butyric Acid Foldamers Terminated with Rhodium(I) N-Heterocyclic Carbene Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Controlling supramolecular filament chirality of hydrogel by co-assembly of enantiomeric aromatic peptides.Journal of nanobiotechnology · 2022Article
- Photo- and Electrochemical Dual-Responsive Iridium Probe for Saccharide Detection.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Article
- Conformational interplay in hybrid peptide-helical aromatic foldamer macrocycles.Chemical science · 2021Article
- Hierarchical communication of chirality for aromatic oligoamide sequences.Nature communications · 2021Article
- Molecular Recognition by Zn(II)-Capped Dynamic Foldamers.ChemistryOpen · 2020Article
- Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide.Chemical science · 2019Article
- Supramolecular chirality transformation driven by monodentate ligand binding to a coordinatively unsaturated self-assembly based onChemical science · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The long-range communication of information, exemplified by signal transduction through membrane-bound receptors, is a central biochemical function. Reversible binding of a messenger ligand induces a local conformational change that is relayed through the receptor, inducing a chemical effect typically several nanometres from the binding site. We report a synthetic receptor mimic that transmits structural information from a boron-based ligand binding site to a spectroscopic reporter located more than 2 nm away. Reversible binding of a diol ligand to the N-terminal binding site induces a screw-sense preference in a helical oligo(aminoisobutyric acid) foldamer, which is relayed to a reporter group at the remote C-terminus, communicating information about the structure and stereochemistry of the ligand. The reversible nature of boronate esterification was exploited to switch the receptor sequentially between left- and right-handed helices, while the exquisite conformational sensitivity of the helical relay allowed the reporter to differentiate even between purine and pyrimidine nucleosides as ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.