ArticleExperimental cell research2013
Bone marrow-derived mesenchymal stem cells enhance angiogenesis via their α6β1 integrin receptor.
Article in Experimental cell research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Overexpression of HIF2α Enhances the Angiogenesis-Promoting Effect of hUC-MSC-Derived Extracellular Vesicles by Stimulating miR-146a.Protein and peptide letters · 2025Article
- Impaired Communication through Gap Junctions Reduces the Angiogenic Potential of the Secretome in Mesenchymal Stromal Cell-Endothelial Cell Interactions In Vitro.Bulletin of experimental biology and medicine · 2024Article
- SETD4 in the Proliferation, Migration, Angiogenesis, Myogenic Differentiation and Genomic Methylation of Bone Marrow Mesenchymal Stem Cells.Stem cell reviews and reports · 2021Article
- Evaluation of CD49f as a novel surface marker to identify functional adipose-derived mesenchymal stem cell subset.Cell proliferation · 2021Article
- Cre mRNA Is Not Transferred by EVs from Endothelial and Adipose-Derived Stromal/Stem Cells during Vascular Network Formation.International journal of molecular sciences · 2021Article
- Mesenchymal stromal cell derived CCL2 is required for accelerated wound healing.Scientific reports · 2020Article
- Pro-angiogenic Activity Discriminates Human Adipose-Derived Stromal Cells From Retinal Pericytes: Considerations for Cell-Based Therapy of Diabetic Retinopathy.Frontiers in cell and developmental biology · 2020Article
- Stem Cell Paracrine Signaling for Treatment of Premature Ovarian Insufficiency.Frontiers in endocrinology · 2020Review
- The Role of MSC Therapy in Attenuating the Damaging Effects of the Cytokine Storm Induced by COVID-19 on the Heart and Cardiovascular System.Frontiers in cardiovascular medicine · 2020Review
- Fibrin-based Bioinks: New Tricks from an Old Dog.International journal of bioprinting · 2020Review
- Role of Cancer Stem Cells in Cholangiocarcinoma and Therapeutic Implications.International journal of molecular sciences · 2019Review
- Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury.Neural regeneration research · 2019Review
- Review
- The therapeutic potential of bone marrow mesenchymal stem cells in premature ovarian failure.Stem cell research & therapy · 2018Review
- Fibroblasts as a practical alternative to mesenchymal stem cells.Journal of translational medicine · 2018Review
- The cytokine secretion profile of mesenchymal stromal cells is determined by surface structure of the microenvironment.Scientific reports · 2018Article
- The role of fibrinolysis inhibition in engineered vascular networks derived from endothelial cells and adipose-derived stem cells.Stem cell research & therapy · 2018Article
- Article
- Microvascular Networks From Endothelial Cells and Mesenchymal Stromal Cells From Adipose Tissue and Bone Marrow: A Comparison.Frontiers in bioengineering and biotechnology · 2018Article
- Vascular Network Formation by Human Microvascular Endothelial Cells in Modular Fibrin Microtissues.ACS biomaterials science & engineering · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Bone marrow-derived mesenchymal stem cells (BMSCs) facilitate the angiogenic response of endothelial cells (ECs) within three-dimensional (3D) matrices in vivo and in engineered tissues in vitro in part through paracrine mediators and by acting as stabilizing pericytes. However, the molecular interactions between BMSCs and nascent tubules during the process of angiogenesis are not fully understood. In this study, we have used a tractable 3D co-culture model to explore the functional role of the α6β1 integrin adhesion receptor on BMSCs in sprouting angiogenesis. We report that knockdown of the α6 integrin subunit in BMSCs significantly reduces capillary sprouting, and causes their failure to associate with the nascent vessels. Furthermore, we demonstrate that the BMSCs with attenuated α6 integrin proliferate at a significantly lower rate relative to either control cells expressing non-targeting shRNA or wild type BMSCs; however, despite adding more cells to compensate for this deficit in proliferation, deficient sprouting persists. Collectively, our findings demonstrate that the α6 integrin subunit in BMSCs is important for their ability to stimulate vessel morphogenesis. This conclusion may have important implications in the optimization of cell-based strategies to promote angiogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.