ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2013
Phylogenomics of Brazilian epidemic isolates of Mycobacterium abscessus subsp. bolletii reveals relationships of global outbreak strains.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
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- Prevalence of nontuberculous mycobacteria and the emergence of rare species in Henan Province, China.Epidemiology and infection · 2024Article
- Population genetic analysis of clinicalFrontiers in cellular and infection microbiology · 2024Article
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- Phylogenomics of nontuberculous mycobacteria respiratory infections in people with cystic fibrosis.Paediatric respiratory reviews · 2023Review
- Optimized analysis parameters of variant calling for whole genome-based phylogeny of Mycobacteroides abscessus.Archives of microbiology · 2022Article
- Genomic Analysis of a Hospital-Associated Outbreak of Mycobacterium abscessus: Implications on Transmission.Journal of clinical microbiology · 2022Article
- Population Genomics ofAnnals of the American Thoracic Society · 2021Article
- Dissemination of Mycobacterium abscessus via global transmission networks.Nature microbiology · 2021Article
- Genomic characterization of sporadic isolates of the dominant clone of Mycobacterium abscessus subspecies massiliense.Scientific reports · 2021Article
- Increased Virulence of Outer Membrane Porin Mutants ofFrontiers in microbiology · 2021Article
- Antimicrobial Susceptibility and Phylogenetic Relations in a German Cohort Infected with Mycobacterium abscessus.Journal of clinical microbiology · 2020Article
- Characterization of integrated prophages within diverse species of clinical nontuberculous mycobacteria.Virology journal · 2020Article
- Genomic Analysis of Mycobacterium abscessus Complex Isolates Collected in Ireland between 2006 and 2017.Journal of clinical microbiology · 2020Article
- Cross-transmission Is Not the Source of New Mycobacterium abscessus Infections in a Multicenter Cohort of Cystic Fibrosis Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Comparative genomics in infectious disease.Current opinion in microbiology · 2020Review
- Complete nontuberculous mycobacteria whole genomes using an optimized DNA extraction protocol for long-read sequencing.BMC genomics · 2019Article
- Advancing Translational Science for Pulmonary Nontuberculous Mycobacterial Infections. A Road Map for Research.American journal of respiratory and critical care medicine · 2019Article
- The complexities and challenges of preventing and treating nontuberculous mycobacterial diseases.PLoS neglected tropical diseases · 2019Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Rapidly growing, non-tuberculous mycobacteria (NTM) in the Mycobacterium abscessus (MAB) species are emerging pathogens that cause various diseases including skin and respiratory infections. The species has undergone recent taxonomic nomenclature refinement, and is currently recognized as two subspecies, M. abscessus subsp. abscessus (MAB-A) and M. abscessus subsp. bolletii (MAB-B). The recently reported outbreaks of MAB-B in surgical patients in Brazil from 2004 to 2009 and in cystic fibrosis patients in the United Kingdom (UK) in 2006 to 2012 underscore the need to investigate the genetic diversity of clinical MAB strains. To this end, we sequenced the genomes of two Brazilian MAB-B epidemic isolates (CRM-0019 and CRM-0020) derived from an outbreak of skin infections in Rio de Janeiro, two unrelated MAB strains from patients with pulmonary infections in the United States (US) (NJH8 and NJH11) and one type MAB-B strain (CCUG 48898) and compared them to 25 publically available genomes of globally diverse MAB strains. Genome-wide analyses of 27,598 core genome single nucleotide polymorphisms (SNPs) revealed that the two Brazilian derived CRM strains are nearly indistinguishable from one another and are more closely related to UK outbreak isolates infecting CF patients than to strains from the US, Malaysia or France. Comparative genomic analyses of six closely related outbreak strains revealed geographic-specific large-scale insertion/deletion variation that corresponds to bacteriophage insertions and recombination hotspots. Our study integrates new genome sequence data with existing genomic information to explore the global diversity of infectious M. abscessus isolates and to compare clinically relevant outbreak strains from different continents.
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