Evidence map›Paper›PMID 24055928›Full record

ReviewPrion

Laboratory activities involving transmissible spongiform encephalopathy causing agents: risk assessment and biosafety recommendations in Belgium.

Amaya Leunda, Bernadette Van Vaerenbergh, Aline Baldo, Stefan Roels, Philippe Herman

Open access · hybridAbstract readReview
In one paragraph

Review in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Amaya LeundaBiosafety and Biotechnology Unit; Institut Scientifique de Santé Publique; Brussels, Belgium.
Bernadette Van VaerenberghBiosafety and Biotechnology Unit; Institut Scientifique de Santé Publique; Brussels, Belgium.
Aline BaldoBiosafety and Biotechnology Unit; Institut Scientifique de Santé Publique; Brussels, Belgium.
Stefan RoelsOrientation and Veterinary Support; National Reference Laboratory for TSE (Belgium & Luxemburg); Veterinary and Agrochemical Research Center; Brussels, Belgium.
Philippe HermanBiosafety and Biotechnology Unit; Institut Scientifique de Santé Publique; Brussels, Belgium.
Institut Scientifique de Santé Publique · BEVeterinary and Agrochemical Research Centre · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the appearance in 1986 of epidemic of bovine spongiform encephalopathy (BSE), a new form of neurological disease in cattle which also affected human beings, many diagnostic and research activities have been performed to develop detection and therapeutic tools. A lot of progress was made in better identifying, understanding and controlling the spread of the disease by appropriate monitoring and control programs in European countries. This paper reviews the recent knowledge on pathogenesis, transmission and persistence outside the host of prion, the causative agent of transmissible spongiform encephalopathies (TSE) in mammals with a particular focus on risk (re)assessment and management of biosafety measures to be implemented in diagnostic and research laboratories in Belgium. Also, in response to the need of an increasing number of European diagnostic laboratories stopping TSE diagnosis due to a decreasing number of TSE cases reported in the last years, decontamination procedures and a protocol for decommissioning TSE diagnostic laboratories is proposed.

Indexed as

AnimalsBelgiumCattleClinical Laboratory ServicesEncephalopathy, Bovine SpongiformHumansPrion DiseasesPrionsRisk AssessmentPrionsbiosafety recommendationscontained useinactivationlaboratory decommissioningrisk assessmenttransmissible spongiform encephalopathy

Identifiers

PMID24055928
PMCPMC3904386
OpenAlexW2113246198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.