ReviewCurrent opinion in cell biology2013
Post-mitotic role of the cell cycle machinery.
Review in Current opinion in cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- CDK3 induces neuronal death and brain atrophy in Alzheimer's disease.Nature aging · 2026Article
- Comparative Transcriptomics Data Profiling Reveals E2F Targets as an Important Biological Pathway Overexpressed in Intellectual Disability Disorder.Bioinformatics and biology insights · 2024Article
- Magnetic transferrin nanoparticles (MTNs) assay as a novel isolation approach for exosomal biomarkers in neurological diseases.Biomaterials research · 2023Article
- Pathological Nuclear Hallmarks in Dentate Granule Cells of Alzheimer's Patients: A Biphasic Regulation of Neurogenesis.International journal of molecular sciences · 2022Article
- When Good Kinases Go Rogue: GSK3, p38 MAPK and CDKs as Therapeutic Targets for Alzheimer's and Huntington's Disease.International journal of molecular sciences · 2021Review
- Core cell cycle machinery is crucially involved in both life and death of post-mitotic neurons.Cellular and molecular life sciences : CMLS · 2020Review
- Genetic Dissection of Alzheimer's Disease UsingInternational journal of molecular sciences · 2020Review
- "Till Death Do Us Part": A Potential Irreversible Link Between Aberrant Cell Cycle Control and Neurodegeneration in the Adult Olfactory Bulb.Frontiers in neuroscience · 2018Review
- Cell cycle proteins moonlight in multiciliogenesis.Science (New York, N.Y.) · 2017Article
- Upregulation of Cdh1 Attenuates Isoflurane-Induced Neuronal Apoptosis and Long-Term Cognitive Impairments in Developing Rats.Frontiers in cellular neuroscience · 2017Article
- Cortical neurons gradually attain a post-mitotic state.Cell research · 2016Article
- Motor phenotypes and molecular networks associated with germline deficiency of Ciz1.Experimental neurology · 2016Article
- Tissue-specific targeting of cell fate regulatory genes by E2f factors.Cell death and differentiation · 2016Article
- Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons.Scientific reports · 2015Article
- Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry.Cell death and differentiation · 2015Article
- Cell cycle gene expression networks discovered using systems biology: Significance in carcinogenesis.Journal of cellular physiology · 2015Article
- Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Transcriptional control of stem cell fate by E2Fs and pocket proteins.Frontiers in genetics · 2015Review
- Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The process of cell division is highly complex. The DNA of the genome must be accurately replicated and segregated into two precisely equal portions; the cytoskeleton must be actively rearranged; and the cellular motor forces that allow the separation of the replicated chromosomes and the splitting of the mother cell into two daughters must be kept under strict spatial and temporal regulation. Not surprisingly for a process of this complexity, there is a wide range of proteins whose location and activity must be accurately controlled to ensure both efficiency and precision. Although the demands placed on these cell cycle proteins are high, once cells such as neurons differentiate they enter a long non-mitotic phase where evolution has conspired to repurpose many of these proteins, leading them to assume new and often unrelated cellular tasks. In neurons there is a wide range of non-cycling functions for these 'cell cycle' proteins and this review covers some of the best-known examples. There is little apparent logic to the second use, but the sheer number of examples suggests that there must be a significant evolutionary advantage to this repurposing strategy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.