ArticleMolecular cell2013
Functionally diverse microRNA effector complexes are regulated by extracellular signaling.
Article in Molecular cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 51 citations in OpenAlex.
- Partners in Silencing: Decoding the Mammalian Argonaute Interactome.Non-coding RNA · 2025Review
- miR-7 is recruited to the high molecular weight RNA-induced silencing complex in CD8RNA (New York, N.Y.) · 2023Article
- MicroRNA-7a2 Contributes to Estrogen Synthesis and Is Modulated by FSH via the JNK Signaling Pathway in Ovarian Granulosa Cells.International journal of molecular sciences · 2022Article
- Identification and Characterization of Abiotic Stress-Responsive NF-YB Family Genes inInternational journal of molecular sciences · 2022Article
- Noncoding RNAs in apoptosis: identification and function.Turkish journal of biology = Turk biyoloji dergisi · 2022Review
- Review
- microRNA-mediated translation repression through GYF-1 and IFE-4 in C. elegans development.Nucleic acids research · 2021Article
- An ortholog of the Vasa intronic gene is required for small RNA-mediated translation repression inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- MicroRNAs: From Mechanism to Organism.Frontiers in cell and developmental biology · 2020Review
- The Role of Dynamic miRISC During Neuronal Development.Frontiers in molecular biosciences · 2020Review
- The viral F-box protein P0 induces an ER-derived autophagy degradation pathway for the clearance of membrane-bound AGO1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- RIP-Chip analysis supports different roles for AGO2 and GW182 proteins in recruiting and processing microRNA targets.BMC bioinformatics · 2019Article
- The dynamic recruitment of TRBP to neuronal membranes mediates dendritogenesis during development.EMBO reports · 2018Article
- Article
- Intracytoplasmic Re-localization of miRISC Complexes.Frontiers in genetics · 2018Review
- Participation of dengue virus NS4B protein in the modulation of immune effectors dependent on ER stress in insect cells.Cell stress & chaperones · 2017Article
- A continuum of mRNP complexes in embryonic microRNA-mediated silencing.Nucleic acids research · 2017Article
- Article
- GW182-Free microRNA Silencing Complex Controls Post-transcriptional Gene Expression during Caenorhabditis elegans Embryogenesis.PLoS genetics · 2016Article
- miRISC and the CCR4-NOT complex silence mRNA targets independently of 43S ribosomal scanning.The EMBO journal · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Because microRNAs (miRNAs) influence the expression of many genes in cells, discovering how the miRNA pathway is regulated is an important area of investigation. We found that the Drosophila miRNA-induced silencing complex (miRISC) exists in multiple forms. A constitutive form, called G-miRISC, is comprised of Ago1, miRNA, and GW182. Two distinct miRISC complexes that lack GW182 are regulated by mitogenic signaling. Exposure of cells to serum, lipids, or the tumor promoter PMA suppressed formation of these complexes. P-miRISC is comprised of Ago1, miRNA, and Loqs-PB, and it associates with mRNAs assembled into polysomes. The other regulated Ago1 complex associates with membranous organelles and is likely an intermediate in miRISC recycling. The formation of these complexes is correlated with a 5- to 10-fold stronger repression of target gene expression inside cells. Taken together, these results indicate that mitogenic signaling regulates the miRNA effector machinery to attenuate its repressive activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.