ArticleNeuron2013
Cellular resolution functional imaging in behaving rats using voluntary head restraint.
Article in Neuron, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of physiological methods in rodent pharmacological MRI studies.Psychopharmacology · 2015Pooled it
- Coordinated Representational Drift Across the Mouse Cortex.bioRxiv : the preprint server for biology · 2026Article
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- Automated head-fixation training system with high levels of animal participation in psychoacoustic tasks.PloS one · 2025Article
- Brain-wide neural recordings in mice navigating physical spaces enabled by robotic neural recording headstages.Nature methods · 2024Article
- Magnetic voluntary head-fixation in transgenic rats enables lifespan imaging of hippocampal neurons.Nature communications · 2024Article
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- Neurons in the primary visual cortex of freely moving rats encode both sensory and non-sensory task variables.PLoS biology · 2023Article
- Meso-Py: Dual Brain Cortical Calcium Imaging in Mice during Head-Fixed Social Stimulus Presentation.eNeuro · 2023Article
- Brain-wide neural recordings in mice navigating physical spaces enabled by a cranial exoskeleton.Research square · 2023Article
- Advances in cellular resolution microscopy for brain imaging in rats.Neurophotonics · 2023Review
- Refinements to rodent head fixation and fluid/food control for neuroscience.Journal of neuroscience methods · 2022Review
- Mouse tail skin wholemount staining and intravital calcium imaging.STAR protocols · 2022Article
- Training protocol for probabilistic Pavlovian conditioning in mice using an open-source head-fixed setup.STAR protocols · 2021Article
- Causal Network Inference for Neural Ensemble Activity.Neuroinformatics · 2021Article
- Article
- New Open-Source Tools: Using Bonsai for Behavioral Tracking and Closed-Loop Experiments.Frontiers in behavioral neuroscience · 2021Article
- Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages.eLife · 2020Article
- A platform for semiautomated voluntary training of common marmosets for behavioral neuroscience.Journal of neurophysiology · 2020Article
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3 authors.
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Abstract
High-throughput operant conditioning systems for rodents provide efficient training on sophisticated behavioral tasks. Combining these systems with technologies for cellular resolution functional imaging would provide a powerful approach to study neural dynamics during behavior. Here we describe an integrated two-photon microscope and behavioral apparatus that allows cellular resolution functional imaging of cortical regions during epochs of voluntary head restraint. Rats were trained to initiate periods of restraint up to 8 s in duration, which provided the mechanical stability necessary for in vivo imaging while allowing free movement between behavioral trials. A mechanical registration system repositioned the head to within a few microns, allowing the same neuronal populations to be imaged on each trial. In proof-of-principle experiments, calcium-dependent fluorescence transients were recorded from GCaMP-labeled cortical neurons. In contrast to previous methods for head restraint, this system can be incorporated into high-throughput operant conditioning systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.