ArticleHeart & lung : the journal of critical care
Subgroup analysis of symptoms and their effect on functioning, exercise capacity, and physical activity in patients with severe chronic obstructive pulmonary disease.
Article in Heart & lung : the journal of critical care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Chronic Obstructive Pulmonary Disease Symptom Cluster Composition, Associated Factors, and Methodologies: A Systematic Review.Western journal of nursing research · 2022Pooled it
- Physical Activity Characteristics across GOLD Quadrants Depend on the Questionnaire Used.PloS one · 2016Trial
- Article
- Identifying the Core Symptoms in Chinese Patients of Chronic Obstructive Pulmonary Disease: A Contemporaneous Symptom Network Analysis.International journal of chronic obstructive pulmonary disease · 2025Article
- Association of Patient-Reported Outcome Patterns and Major Clinical Factors with Frailty in Stable COPD.International journal of chronic obstructive pulmonary disease · 2025Article
- Symptom Clusters, Psychological Distress, and Quality of Life in Patients with Atrial Fibrillation.Healthcare (Basel, Switzerland) · 2023Article
- Moving beyond Table 1: A critical review of the literature addressing social determinants of health in chronic condition symptom cluster research.Nursing inquiry · 2023Review
- Characterizing shared and distinct symptom clusters in common chronic conditions through natural language processing of nursing notes.Research in nursing & health · 2021Article
- The Expressions of Hope in the Face of Complex Surgery: Experiences of Patients and Their Loved Ones.Journal of patient experience · 2019Article
- An eHealth Intervention to Promote Physical Activity and Social Network of Single, Chronically Impaired Older Adults: Adaptation of an Existing Intervention Using Intervention Mapping.JMIR research protocols · 2017Article
- Symptom profiles and inflammatory markers in moderate to severe COPD.BMC pulmonary medicine · 2016Observational
- Distinct symptom experiences in subgroups of patients with COPD.International journal of chronic obstructive pulmonary disease · 2016Article
- Symptom cluster, healthcare use and mortality in patients with severe chronic obstructive pulmonary disease.Journal of clinical nursing · 2014Article
- Experience of insomnia, symptom attribution and treatment preferences in individuals with moderate to severe COPD: a qualitative study.Patient preference and adherence · 2014Article
- Diaphragmatic mobility: relationship with lung function, respiratory muscle strength, dyspnea, and physical activity in daily life in patients with COPD.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
- Effect of symptoms on physical performance in COPD.Heart & lung : the journal of critical careObservational
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about symptom clusters and their effect on outcomes in people with chronic obstructive pulmonary disease (COPD). PURPOSES: To determine whether subgroups of patients with COPD could be identified by symptom ratings, whether they differed on selected demographic and clinical characteristics, and whether they differed on functioning, exercise capacity, and physical activity.
methodSubjects with severe COPD (n = 596) were drawn from the National Emphysema Treatment Trial dataset. Data were drawn from questionnaires and clinical measures.
resultsTwo subgroup clusters emerged from four symptoms. Mean age and the proportion of participants with higher education, higher income levels, and using oxygen at rest were significantly different between subgroups. Participants with high levels of symptoms had lower functioning and decreased exercise capacity. Symptom cluster subgroups were significantly associated with social functioning.
conclusionThese findings suggest that screening for high levels of symptoms may be important in patients with severe COPD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.