Evidence map›Paper›PMID 24054860›Full record

ReviewLeukemia research2013

Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL).

Krystyna Mazan-Mamczarz, Ronald B Gartenhaus

Abstract readReview
In one paragraph

Review in Leukemia research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Review
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  5. Article
  6. Article
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  8. Article
  9. Review
  10. Article
  11. Cobomarsen, an Oligonucleotide Inhibitor of miR-155, Slows DLBCL Tumor Cell GrowthClinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
  12. Review
  13. MiRNA-340-5p mediates the functional and infiltrative promotion of tumor-infiltrating CD8Journal of experimental & clinical cancer research : CR · 2020
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Krystyna Mazan-MamczarzMarlene & Stewart Greenebaum Cancer Center, Department of Medicine, University of Maryland, Baltimore, MD 21201, USA. Electronic address: kmamczarz@som.umaryland.edu.
Ronald B Gartenhaus

Funding

UNIVERSITY OF MARYLAND GREENEBAUM CANCER CENTERSUPPORT GRANTP30CA134274 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI FEYRUZ VIRGILIA RASSOOL · 2008 to 2026
$51.0M
Alcohol Consumption and Risk of NHL: Role of MTOR DysfunctionR01AA017972 · NIAAA · UNIVERSITY OF MARYLAND BALTIMORE · PI GARTENHAUS, RONALD B · 2009 to 2013
$1.7M
MAP Kinase Signaling in Lymphoma: A Novel Therapeutic ParadigmR01CA164311 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI EVENS, ANDREW M, GARTENHAUS, RONALD B · 2012 to 2015
$1.4M
NCI NIH HHS P30 CA134274NCI NIH HHS R01 CA164311NCI NIH HHS R01CA164311NIAAA NIH HHS R01 AA017972NIAAA NIH HHS R01AA017972
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small endogenous RNA molecules that regulate gene expression at the post-transcriptional level through its sequence complementation with target mRNAs. An individual miRNA species can simultaneously influence the expression of multiple genes and conversely, several miRNAs can synchronously control expression of specific gene product mRNA levels. Thus, miRNAs expression in cells has to be precisely regulated and alterations in miRNA levels may cause an aberrant expression of genes involved in oncogenic pathways and consequently result in cancer development. Indeed, miRNA expression is often deregulated in many cancers, including B-cell lymphomas. Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous group of B-cell lymphomas with different genetic backgrounds, morphologic features, and responses to therapy. Over the past decade, miRNAs emerged as a new tool for understanding DLBCL biology, and promising candidate molecular markers in DLBCL classification and treatment. In this review, we will focus on miRNAs aberrantly expressed in DLBCL and discuss the putative mechanisms of this deregulation. Additionally, we will summarize miRNAs' involvement in the identification of DLBCL subgroups, and their potential role as diagnostic/prognostic biomarkers as well as specific therapeutic targets for DLBCL.

Indexed as

Gene Expression Regulation, NeoplasticAnimalsHumansLymphoma, Large B-Cell, DiffuseMicroRNAsMicroRNAsDLBCLLymphomaMicrorna

Identifiers

PMID24054860
PMCPMC3856880

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.