Evidence map›Paper›PMID 24054151›Full record

ReviewAdvances in pharmacology (San Diego, Calif.)2013

Localization and expression of VMAT2 aross mammalian species: a translational guide for its visualization and targeting in health and disease.

Martin K-H Schafer, Eberhard Weihe, Lee E Eiden

Open access · greenAbstract readReview
In one paragraph

Review in Advances in pharmacology (San Diego, Calif.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
41.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Article
  3. A Closer Look at Histamine inInternational journal of molecular sciences · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. A novel missense variant inJIMD reports · 2019
    Article
  13. Going Too Far Is the Same as Falling ShortFrontiers in cellular neuroscience · 2019
    Review
  14. 5-HTRMolecular brain · 2018
    Article
  15. Article
  16. [ACS chemical neuroscience · 2017
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Martin K-H SchaferInstitute of Anatomy and Cell Biology, Philipps-University Marburg, Marburg, Germany.
Eberhard Weihe
Lee E Eiden
Philipps University of Marburg · DENational Institute of Mental Health · US

Funding

Chemical Coding Of NeurotransmissionZIAMH002386 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI EIDEN, LEE E. · 2009 to 2025
$25.6M
Intramural NIH HHS Z99 MH999999Intramural NIH HHS ZIA MH002386
6 · The paper itself

Abstract

VMAT2 is the vesicular monoamine transporter that allows DA, NE, Epi, His, and 5-HT uptake into neurons and endocrine cells. A second isoform, VMAT1, has similar structure and function, but does not recognize histamine as a substrate. VMAT1 is absent from neurons, and its major function appears to be in endocrine cells, that is, enterochromaffin cells, which scavenge 5-HT, but not histamine, from dietary sources. This chapter provides an update on the neuroanatomical distribution of VMAT2 across various mammalian species, including human, primate, pig, rat, and mouse. When necessary, VMAT1 expression is provided as a contrast. The main purpose of this chapter is to allow clinicians, in particular endocrinologists and diagnosing neuroradiologists and neuropathologists, an acquaintanceship with the possibilities for VMAT2 as a target for in vivo imaging, and drug development, based on this updated information.

Indexed as

Adrenergic Uptake InhibitorsAnimalsBrainDigestive SystemHumansPeripheral Nervous SystemTetrabenazineVesicular Monoamine Transport ProteinsAdrenergic Uptake InhibitorsTetrabenazineVesicular Monoamine Transport ProteinsDopamineEpinephrineHistamineNeuroendocrine tumors (NETs)NorepinephrinePancreasSerotoninTetrabenazineVMAT2

Identifiers

PMID24054151
PMCPMC3928124
OpenAlexW30381592

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.