ArticleBMC medical genetics2013
Evaluation of DNA damage in COPD patients and its correlation with polymorphisms in repair genes.
Article in BMC medical genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- OGG1S326C variant frequent in human populations facilitates inflammatory responses due to its extended interaction with DNA substrate.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Unveiling mechanisms of lung aging in COPD: A promising target for therapeutics development.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Implications of DNA damage in chronic lung disease.Frontiers in cell and developmental biology · 2024Review
- Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.Nature cell biology · 2020Article
- Slow freezing versus vitrification for the cryopreservation of zebrafish (Danio rerio) ovarian tissue.Scientific reports · 2019Article
- PMEnvironmental science and pollution research international · 2019Article
- The DNA repair transcriptome in severe COPD.The European respiratory journal · 2018Article
- Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention.Free radical biology & medicine · 2018Article
- RNAseq analysis of bronchial epithelial cells to identify COPD-associated genes and SNPs.BMC pulmonary medicine · 2018Article
- The Investigation of Polymorphisms in DNA Repair Genes (XRCC1, APE1 and XPD) in Women with Polycystic Ovary SyndromeAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Genetic Polymorphisms of X-ray Repair Cross-Complementing Group 1 and Apurinic/Apyrimidinic Endonuclease-1 in Chronic Obstructive Pulmonary Disease.Inflammation · 2016Article
- DNA damage and repair capacity in lymphocyte of chronic obstructive pulmonary diseases patients during physical exercise with oxygen supplementation.Multidisciplinary respiratory medicine · 2016Article
- Prognostic utility of admission cell-free DNA levels in patients with chronic obstructive pulmonary disease exacerbations.International journal of chronic obstructive pulmonary disease · 2016Observational
- Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science.Journal of toxicology and environmental health. Part B, Critical reviews · 2016Review
- DNA damage and cellular abnormalities in tuberculosis, lung cancer and chronic obstructive pulmonary disease.Multidisciplinary respiratory medicine · 2015Article
- A comparison of the human buccal cell assay and the pollen abortion assay in assessing genotoxicity in an urban-rural gradient.International journal of environmental research and public health · 2014Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated a potential link between genetic polymorphisms in genes XRCC1 (Arg399Gln), OGG1 (Ser326Cys), XRCC3 (Thr241Met), and XRCC4 (Ile401Thr) with the level of DNA damage and repair, accessed by comet and micronucleus test, in 51 COPD patients and 51 controls.
methodsPeripheral blood was used to perform the alkaline and neutral comet assay; and genetic polymorphisms by PCR/RFLP. To assess the susceptibility to exogenous DNA damage, the cells were treated with methyl methanesulphonate for 1-h or 3-h. After 3-h treatment the % residual damage was calculated assuming the value of 1-h treatment as 100%. The cytogenetic damage was evaluated by buccal micronucleus cytome assay (BMCyt).
resultsCOPD patients with the risk allele XRCC1 (Arg399Gln) and XRCC3 (Thr241Met) showed higher DNA damage by comet assay. The residual damage was higher for COPD with risk allele in the four genes. In COPD patients was showed negative correlation between BMCyt (binucleated, nuclear bud, condensed chromatin and karyorrhexic cells) with pulmonary function and some variant genotypes.
conclusionOur results suggest a possible association between variant genotypes in XRCC1 (Arg399Gln), OGG1 (Ser326Cys), XRCC3 (Thr241Met), and XRCC4 (Ile401Thr), DNA damage and progression of COPD.
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