ArticleBMC infectious diseases2013
High clustering rates of multidrug-resistant Mycobacterium tuberculosis genotypes in Panama.
Article in BMC infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Spatial spillover effects and regional differences of tuberculosis health education levels among China's floating population: a spatial lag model study (2014-2017).BMC public health · 2026Article
- Heterogeneity of Mycobacterium tuberculosis Strains Circulating in Panama's Western Region.The American journal of tropical medicine and hygiene · 2023Article
- Genetic Diversity ofFrontiers in cellular and infection microbiology · 2022Article
- Circulation ofPathogens and global health · 2019Review
- Simplified Model to Survey Tuberculosis Transmission in Countries Without Systematic Molecular Epidemiology Programs.Emerging infectious diseases · 2019Article
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- Mycobacterium tuberculosis isolates from single outpatient clinic in Panama City exhibit wide genetic diversity.The American journal of tropical medicine and hygiene · 2014Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis continues to be one of the leading causes of death worldwide and in the American region. Although multidrug-resistant tuberculosis (MDR-TB) remains a threat to TB control in Panama, few studies have focused in typing MDR-TB strains. The aim of our study was to characterize MDR Mycobacterium tuberculosis clinical isolates using PCR-based genetic markers.
methodsFrom 2002 to 2004, a total of 231 Mycobacterium tuberculosis isolates from TB cases country-wide were screened for antibiotic resistance, and MDR-TB isolates were further genotyped by double repetitive element PCR (DRE-PCR), (GTG)5-PCR and spoligotyping.
resultsA total of 37 isolates (0.85%) were resistant to both isoniazid (INH) and rifampicin (RIF). Among these 37 isolates, only two (5.4%) were resistant to all five drugs tested. Dual genotyping using DRE-PCR and (GTG)5-PCR of MDR Mycobacterium tuberculosis isolates revealed eight clusters comprising 82.9% of the MDR-TB strain collection, and six isolates (17.1%) showed unique fingerprints. The spoligotyping of MDR-TB clinical isolates identified 68% as members of the 42 (LAM9) family genotype.
conclusionOur findings suggest that MDR Mycobacterium tuberculosis is highly clustered in Panama's metropolitan area corresponding to Panama City and Colon City, and our study reveals the genotype distribution across the country.
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