ArticleBMC genomics2013
Extensively duplicated and transcriptionally active recent lateral gene transfer from a bacterial Wolbachia endosymbiont to its host filarial nematode Brugia malayi.
Article in BMC genomics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Ghosts of symbionts past: the hidden history of the dynamic association between filarial nematodes and their Wolbachia endosymbionts.G3 (Bethesda, Md.) · 2025Article
- Suppression of cytoplasmic incompatibility in the leaf-mining flyRoyal Society open science · 2025Article
- Improved metagenome assemblies through selective enrichment of bacterial genomic DNA from eukaryotic host genomic DNA using ATAC-seq.Frontiers in microbiology · 2024Article
- Article
- Horizontally Acquired Cellulases Assist the Expansion of Dietary Range in Pristionchus Nematodes.Molecular biology and evolution · 2022Article
- Article
- Nearly Complete Genome Sequence of Brugia malayi Strain FR3.Microbiology resource announcements · 2020Article
- Sex chromosome evolution in parasitic nematodes of humans.Nature communications · 2020Article
- Correlation of Parasite Burden, kDNA Integration, Autoreactive Antibodies, and Cytokine Pattern in the Pathophysiology of Chagas Disease.Frontiers in microbiology · 2019Article
- Grafting or pruning in the animal tree: lateral gene transfer and gene loss?BMC genomics · 2018Article
- Draft genome sequence of the Wolbachia endosymbiont of Wuchereria bancrofti wWb.Pathogens and disease · 2017Article
- Aligner optimization increases accuracy and decreases compute times in multi-species sequence data.Microbial genomics · 2017Article
- Retrotransposons Are the Major Contributors to the Expansion of theG3 (Bethesda, Md.) · 2017Article
- Review
- Lessons from the genomes and transcriptomes of filarial nematodes.Molecular and biochemical parasitology · 2017Review
- Targeted Enrichment and Sequencing of Recent Endosymbiont-Host Lateral Gene Transfers.Scientific reports · 2017Article
- Removing the needle from the haystack: Enrichment of Wolbachia endosymbiont transcripts from host nematode RNA by Cappable-seq™.PloS one · 2017Article
- Genomic evidence for plant-parasitic nematodes as the earliest Wolbachia hosts.Scientific reports · 2016Article
- Population Genomics of Infectious and Integrated Wolbachia pipientis Genomes in Drosophila ananassae.Genome biology and evolution · 2015Article
- The evolution of parasitism in Nematoda.Parasitology · 2015Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundLymphatic filariasis is a neglected tropical disease afflicting more than 120 million people, while another 1.3 billion people are at risk of infection. The nematode worm Brugia malayi is one of the causative agents of the disease and exists in a mutualistic symbiosis with Wolbachia bacteria. Since extensive lateral gene transfer occurs frequently between Wolbachia and its hosts, we sought to measure the extent of such LGT in B. malayi by whole genome sequencing of Wolbachia-depleted worms.
resultsA considerable fraction (at least 115.4-kbp, or 10.6%) of the 1.08-Mbp Wolbachia wBm genome has been transferred to its nematode host and retains high levels of similarity, including 227 wBm genes and gene fragments. Complete open reading frames were transferred for 32 of these genes, meaning they have the potential to produce functional proteins. Moreover, four transfers have evidence of life stage-specific regulation of transcription at levels similar to other nematode transcripts, strengthening the possibility that they are functional.
conclusionsThere is extensive and ongoing transfer of Wolbachia DNA to the worm genome and some transfers are transcribed in a stage-specific manner at biologically relevant levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.