SynthesisGenetic testing and molecular biomarkers2013
Association between interleukin-6 gene polymorphisms and bone mineral density: a meta-analysis.
Synthesis in Genetic testing and molecular biomarkers, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association of lactase 13910 C/T polymorphism with bone mineral density and fracture risk: a meta-analysis.Journal of genetics · 2017Pooled it
- Validation of Osteoporosis associated SNPs candidates from Decisive Gene Strategy using Taiwan Biobank.International journal of medical sciences · 2026Article
- [Ferroptosis-related genes in osteoporosis: a bioinformatics analysis andZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Risk factors associated with low bone mineral density in children with idiopathic scoliosis: a scoping review.BMC musculoskeletal disorders · 2023Article
- Article
- Osteopontin, a bridge links osteoarthritis and osteoporosis.Frontiers in endocrinology · 2022Review
- Dynamic changes of inflammatory response and oxidative stress induced by methicillin-resistant Staphylococcus aureus in mice.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022Article
- No Interaction Effect between Interleukin-6 Polymorphisms and Acid Ash Diet with Bone Resorption Marker in Postmenopausal Women.International journal of environmental research and public health · 2021Article
- Cytokines in Inflammatory Disease.International journal of molecular sciences · 2019Review
- [Correlation analysis between interleukin 6 polymorphism and adolescent idiopathic scoliosis susceptibility and bracing effectiveness].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018Article
- Soluble Inflammatory Markers and Risk of Incident Fractures in Older Adults: The Cardiovascular Health Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- The association between interleukin 6 -174 G/C gene polymorphism and the risk of osteoporosis: A meta-analysis.Journal of Taibah University Medical Sciences · 2017Article
- Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population.Lipids in health and disease · 2014Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMany studies have examined the association between interleukin-6 (IL-6) gene polymorphisms and bone mineral density (BMD). However, the results remain conflicting. To assess the relationship more precisely, a meta-analysis was performed.
methodsThe PubMed, Embase, Chinese BioMedical Literature (CBM), Wanfang, and China National Knowledge Infrastructure (CNKI) database were searched for relevant articles published up to March 2013. Weighted mean difference (WMD) and 95% confidence interval (95% CI) were calculated using a fixed-effects or random-effects model.
resultsA total of 16 articles with 11,957 subjects were investigated in this meta-analysis. Overall, -634C/G polymorphism was significantly associated with BMD at the femoral neck (WMD, -0.016 g/cm(2); 95% CI, -0.028 to -0.003 g/cm(2)), lumbar spine (WMD, -0.049 g/cm(2); 95% CI, -0.069 to -0.030 g/cm(2)), and whole body (WMD, -0.023 g/cm(2); 95% CI, -0.037 to -0.009 g/cm(2)) for GG versus CC+CG. In subgroup analyses stratified by ethnicity, individuals carrying -634GG genotype had a significantly lower mean BMD at any skeletal site examined, compared with individuals with -634CC or -634CG genotype in Asian populations. For -174G/C polymorphism, the BMD differences between CC+CG and GG genotype were 0.004 g/cm(2) at the distal radius (95% CI, 0.004 to 0.005 g/cm(2)), 0.011 g/cm(2) at the trochanter (95% CI, 0.002 to 0.020 g/cm(2)), and 0.017 g/cm(2) at the Ward's triangle (95% CI, 0.003 to 0.032 g/cm(2)). No significant publication bias was observed in either the -634C/G or -174G/C polymorphism.
conclusionsThis suggests that there are modest effects of the -634C/G and -174G/C polymorphisms on BMD. Large-scale and well-designed studies are required to further investigate gene-gene and gene-environment interactions on IL-6 polymorphisms and BMD in various populations.
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