ArticleBJU international2014
Nephron-sparing management vs radical nephroureterectomy for low- or moderate-grade, low-stage upper tract urothelial carcinoma.
Article in BJU international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- A systematic review and meta-analysis of oncological and renal function outcomes obtained after segmental ureterectomy versus radical nephroureterectomy for upper tract urothelial carcinoma.European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology · 2016Pooled it
- Comparative analysis of oncologic outcomes: kidney-sparing surgery versus radical nephroureterectomy for localized high-risk upper tract urothelial carcinoma.Frontiers in oncology · 2026Article
- Endoscopic ablation versus nephroureterectomy in localized low-grade upper tract urothelial carcinoma: a comparison in terms of cancer-specific and other-cause mortality.World journal of urology · 2025Article
- The Recurrence Rates at Three Years for the Conservatively Managed UTUC Cases Using NBI-Assisted Flexible Ureteroscopy and Holmium Laser Vaporization.Medicina (Kaunas, Lithuania) · 2024Article
- Nephron-sparing ureteroscopic surgery vs. radical nephroureterectomy: comparable survival-outcomes in upper tract urothelial carcinoma.World journal of urology · 2023Article
- Kidney-sparing surgery for distal high-risk ureteral carcinoma: Clinical efficacy and preliminary experiences in 22 patients.Cancer medicine · 2023Article
- Treatment Patterns, Outcomes, and Costs Associated With Localized Upper Tract Urothelial Carcinoma.JNCI cancer spectrum · 2021Article
- Conservative Treatment for Upper Urinary Tract Urothelial Carcinoma.European urology open science · 2021Article
- Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region.Scientific reports · 2021Article
- Nephron-sparing surgery for the management of upper tract urothelial carcinoma: an outline of surgical technique and review of outcomes.Translational andrology and urology · 2020Review
- Controversies in management of the bladder cuff at nephroureterectomy.Translational andrology and urology · 2020Review
- UGN-101 (mitomycin gel): a novel treatment for low-grade upper tract urothelial carcinoma.Therapeutic advances in medical oncology · 2020Review
- Oncologic outcomes comparison of partial ureterectomy and radical nephroureterectomy for urothelial carcinoma.BMC urology · 2019Article
- Influence of the Body Mass Index and its Effect on Tumor Characteristics and Survival among a Population with Access to Surgical Management of Upper Tract Urothelial Carcinoma.Current urology · 2019Article
- Treatment utilization and overall survival in patients receiving radical nephroureterectomy versus endoscopic management for upper tract urothelial carcinoma: evaluation of updated treatment guidelines.World journal of urology · 2019Article
- Renal function recovery after radical nephroureterectomy for upper tract urothelial carcinoma.World journal of urology · 2018Article
- A Novel Technique to Improve the Processing of Minute Ureteroscopic Biopsies.Pathology oncology research : POR · 2018Article
- Conservative treatment of upper urinary tract carcinoma: Long-term results.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017Article
- Segmental ureteroileal conduit resection for the treatment of distal upper urinary tract recurrence of bladder cancer following cystectomy.Chinese journal of cancer · 2016Article
- [Surgical management for upper urinary tract transitional cell carcinoma].Der Urologe. Ausg. A · 2015Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo compare overall and cancer-specific outcomes between patients with upper tract urothelial carcinoma (UTUC) managed with either radical nephroureterectomy (RNU) or nephron-sparing measures (NSM) using a large population-based dataset. PATIENTS AND
methodsUsing Surveillance, Epidemiology, and End Results (SEER) data, patients diagnosed with low- or moderate-grade, localised non-invasive UTUC were stratified into two groups: those treated with RNU or NSM (observation, endoscopic ablation, or segmental ureterectomy). Cancer-specific mortality (CSM) and other-cause mortality (OCM) rates were determined using cumulative incidence estimators. Adjusting for clinical and pathological characteristics, the associations between surgical type, all-cause mortality and CSM were tested using Cox regressions and Fine and Gray regressions, respectively.
resultsOf 1227 patients [mean (sd) age 70.2 (11.00) years, 63.2% male] meeting inclusion criteria, 907 (73.9%) and 320 (26.1%) patients underwent RNU and NSM for low- or moderate-grade, low-stage UTUC from 1992 to 2008. Patients undergoing NSM were older (mean age 71.6 vs 69.7 years, P < 0.01) with a greater proportion of well-differentiated tumours (26.3% vs 18.0%, P = 0.001). While there were differences in OCM between the groups (P < 0.01), CSM trends were equivalent. After adjustment, RNU treatment was associated with improved non-cancer cause survival [hazard ratio (HR) 0.78, confidence interval [CI] 0.64-0.94) while no association with CSM was demonstrable (HR 0.89, CI 0.63-1.26).
conclusionsPatients with low- or moderate-grade, low-stage UTUC managed through NSM are older and are more likely to die of other causes, but they have similar CSM rates to those patients managed with RNU. These data may be useful when counselling patients with UTUC with significant competing comorbidities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.