ArticleThe journal of physical chemistry. B2013
Infrared metrics for fixation-free liver tumor detection.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Cohort-Scale Spatial Autocorrelation for Tumor Prediction in Mid-Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fast Mid-Infrared Spectral Probe Decisions Match H&E Stain Results for Keratinocytic Carcinoma.Journal of biophotonics · 2026Article
- IR Spectroscopy and Linear Support Vector Machine Analysis of Colorectal Liver Metastasis.The journal of physical chemistry. B · 2026Article
- Ex Vivo Assessment of Keratinocytic Carcinomas Using a Fast Mid-Infrared Probe.Journal of biophotonics · 2026Article
- Linear Support Vector Machine Model of an IR Spectral Library: Application to Skin Cancer.ACS omega · 2025Article
- Nuclei detection in hepatocellular carcinoma and dysplastic liver nodules in histopathology images using bootstrap regression.Histology and histopathology · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Infrared (IR) spectroscopic imaging of human liver tissue slices has been used to identify and characterize liver tumors. Liver tissue, containing a liver metastasis of breast origin (mucinous carcinoma), was surgically removed from a consenting patient and frozen without formalin fixation or dehydration procedures, so that lipids and water remained in the tissues. A set of IR metrics (ratios of various IR peaks) was determined for tumors in fixation-free liver tissues. K-means cluster analysis was used to tell tumor from nontumor. In this case, there was a large reduction in lipid content upon going from nontumor to tumor tissue, and a well-resolved IR spectrum of nontumor liver lipid was obtained and analyzed. These IR metrics may someday guide work on IR spectroscopic diagnostics on patients in the operating room. This work also suggests utility for these methods beyond the identification of liver tumors, perhaps in the study of liver lipids.
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