ArticleBMC evolutionary biology2013
Spatial aspects of prebiotic replicator coexistence and community stability in a surface-bound RNA world model.
Article in BMC evolutionary biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- The dynamics of prebiotic take-off: the transfer of functional RNA communities from mineral surfaces to vesicles.Communications biology · 2025Article
- The automatic parameter-exploration with a machine-learning-like approach: Powering the evolutionary modeling on the origin of life.PLoS computational biology · 2021Article
- Catalytic promiscuity in the RNA World may have aided the evolution of prebiotic metabolism.PLoS computational biology · 2021Article
- From self-replication to replicator systems en route to de novo life.Nature reviews. Chemistry · 2020Review
- Dynamics and stability in prebiotic information integration: an RNA World model from first principles.Scientific reports · 2020Article
- To save or not to save your family member's life? Evolutionary stability of self-sacrificing life history strategy in monogamous sexual populations.BMC evolutionary biology · 2019Article
- Ecology and Evolution in the RNA World Dynamics and Stability of Prebiotic Replicator Systems.Life (Basel, Switzerland) · 2017Review
- Co-operation between Polymerases and Nucleotide Synthetases in the RNA World.PLoS computational biology · 2016Article
- Template directed replication supports the maintenance of the metabolically coupled replicator system.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2015Article
- In silico ribozyme evolution in a metabolically coupled RNA population.Biology direct · 2015Article
- Chasing the Origin of Viruses: Capsid-Forming Genes as a Life-Saving Preadaptation within a Community of Early Replicators.PloS one · 2015Article
- Phenotype/genotype sequence complementarity and prebiotic replicator coexistence in the metabolically coupled replicator system.BMC evolutionary biology · 2014Article
- Evolution of functional diversification within quasispecies.Genome biology and evolution · 2014Article
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2 authors.
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Abstract
backgroundThe coexistence of macromolecular replicators and thus the stability of presumed prebiotic replicator communities have been shown to critically depend on spatially constrained catalytic cooperation among RNA-like modular replicators. The necessary spatial constraints might have been supplied by mineral surfaces initially, preceding the more effective compartmentalization in membrane vesicles which must have been a later development of chemical evolution.
resultsUsing our surface-bound RNA world model - the Metabolic Replicator Model (MRM) platform - we show that the mobilities on the mineral substrate surface of both the macromolecular replicators and the small molecules of metabolites they produce catalytically are the key factors determining the stable persistence of an evolvable metabolic replicator community.
conclusionThe effects of replicator mobility and metabolite diffusion on different aspects of replicator coexistence in MRM are determined, including the maximum attainable size of the metabolic replicator system and its resistance to the invasion of parasitic replicators. We suggest a chemically plausible hypothetical scenario for the evolution of the first protocell starting from the surface-bound MRM system.
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