ArticleSupplements to Clinical neurophysiology2013
Converging evidence for gamma synchrony deficits in schizophrenia.
Article in Supplements to Clinical neurophysiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Quantitative electroencephalography parameters as neurophysiological biomarkers of schizophrenia-related deficits: A Phase II substudy of patients treated with iclepertin (BI 425809).Translational psychiatry · 2022Trial
- 40-Hz auditory stimulation for intracranial interictal activity: A pilot study.Acta neurologica Scandinavica · 2021Trial
- Δ9-THC Disrupts Gamma (γ)-Band Neural Oscillations in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Trial
- The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures.Schizophrenia (Heidelberg, Germany) · 2025Article
- Alterations in Gray Matter Structure Linked to Frequency-Specific Cortico-Subcortical Connectivity in Schizophrenia via Multimodal Data Fusion.Neuroinformatics · 2025Article
- Discovery of VU6024578/BI02982816: An mGluJournal of medicinal chemistry · 2024Article
- Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis.Schizophrenia bulletin · 2024Article
- Effects of Memantine on the Auditory Steady-State and Harmonic Responses to 40 Hz Stimulation Across Species.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Kenya Psychosis-Risk Outcomes Study (KePROS): Development of an Accelerated Medicine Partnership Schizophrenia-Aligned Project in Africa.Schizophrenia bulletin open · 2024Article
- Auditory Steady-State Responses in Schizophrenia: An Updated Meta-Analysis.Brain sciences · 2023Review
- Cortical connectomic mediations on gamma band synchronization in schizophrenia.Translational psychiatry · 2023Article
- Aberrant attentional modulation of the auditory steady state response (ASSR) is related to auditory hallucination severity in the first-episode schizophrenia-spectrum.Journal of psychiatric research · 2022Article
- Perineuronal Nets in the Prefrontal Cortex of a Schizophrenia Mouse Model: Assessment of Neuroanatomical, Electrophysiological, and Behavioral Contributions.International journal of molecular sciences · 2021Article
- Time Irreversibility of Resting-State Activity in the Healthy Brain and Pathology.Frontiers in physiology · 2019Article
- Test-retest reliability of time-frequency measures of auditory steady-state responses in patients with schizophrenia and healthy controls.NeuroImage. Clinical · 2019Article
- Cortical volume and 40-Hz auditory-steady-state responses in patients with schizophrenia and healthy controls.NeuroImage. Clinical · 2019Article
- Auditory steady state response deficits are associated with symptom severity and poor functioning in patients with psychotic disorder.Schizophrenia research · 2018Article
- Differences of temporal dynamics and signal complexity of gamma band oscillations in first-episode psychosis during a working memory task.Journal of neural transmission (Vienna, Austria : 1996) · 2017Article
- MEG and EEG demonstrate similar test-retest reliability of the 40Hz auditory steady-state response.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- 40 Hz Auditory Steady-State Response Is a Pharmacodynamic Biomarker for Cortical NMDA Receptors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
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4 authors.
Funding
Abstract
backgroundIn electroencephalogram (EEG) studies of auditory steady-state responses (ASSRs), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40 Hz frequency where these responses resonate. In addition, studies of the transient gamma-band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma-band abnormalities in schizophrenia.
methodsEEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet wavelet transformations, were used to derive total power and phase-locking measures.
resultsRelative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups.
conclusions40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.
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