ArticleStem cell reports2013
Identification of novel imprinted differentially methylated regions by global analysis of human-parthenogenetic-induced pluripotent stem cells.
Article in Stem cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Generation of developmentally competent oocytes and fertile mice from parthenogenetic embryonic stem cells.Protein & cell · 2021Article
- Identification of potential transcription factors that enhance human iPSC generation.Scientific reports · 2020Article
- IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions.Nucleic acids research · 2020Article
- Retrotransposons in pluripotent stem cells.Cell regeneration (London, England) · 2020Review
- Modeling allele-specific expression at the gene and SNP levels simultaneously by a Bayesian logistic mixed regression model.BMC bioinformatics · 2019Article
- Technical advances contribute to the study of genomic imprinting.PLoS genetics · 2019Review
- Alteration of Genomic Imprinting Status of Human Parthenogenetic Induced Pluripotent Stem Cells during Neural Lineage Differentiation.International journal of stem cells · 2019Article
- Two approaches reveal a new paradigm of 'switchable or genetics-influenced allele-specific DNA methylation' with potential in human disease.Cell discovery · 2017Article
- Parent-of-Origin DNA Methylation Dynamics during Mouse Development.Cell reports · 2016Article
- Pervasive polymorphic imprinted methylation in the human placenta.Genome research · 2016Article
- Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57.BMC medical genetics · 2016Article
- Deletion of the Snord116/SNORD116 Alters Sleep in Mice and Patients with Prader-Willi Syndrome.Sleep · 2016Article
- Maternal transcription of non-protein coding RNAs from the PWS-critical region rescues growth retardation in mice.Scientific reports · 2016Article
- An integrative analysis of reprogramming in human isogenic system identified a clone selection criterion.Cell cycle (Georgetown, Tex.) · 2016Article
- Variations in the Intragene Methylation Profiles Hallmark Induced Pluripotency.BioMed research international · 2015Article
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- The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome.Nature genetics · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Parental imprinting is an epigenetic phenomenon by which genes are expressed in a monoallelic fashion, according to their parent of origin. DNA methylation is considered the hallmark mechanism regulating parental imprinting. To identify imprinted differentially methylated regions (DMRs), we compared the DNA methylation status between multiple normal and parthenogenetic human pluripotent stem cells (PSCs) by performing reduced representation bisulfite sequencing. Our analysis identified over 20 previously unknown imprinted DMRs in addition to the known DMRs. These include DMRs in loci associated with human disorders, and a class of intergenic DMRs that do not seem to be related to gene expression. Furthermore, the study showed some DMRs to be unstable, liable to differentiation or reprogramming. A comprehensive comparison between mouse and human DMRs identified almost half of the imprinted DMRs to be species specific. Taken together, our data map novel DMRs in the human genome, their evolutionary conservation, and relation to gene expression.
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