ArticleStem cell reports2013
Rebuilding pluripotency from primordial germ cells.
Article in Stem cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- High resolution multi-scale profiling of embryonic germ cell-like cell derivation reveals pluripotent state transitions in humans.Stem cell reports · 2026Article
- Low-input and single-cell methods for Infinium DNA methylation BeadChips.Nucleic acids research · 2024Article
- Transposable elements in early human embryo development and embryo models.Current opinion in genetics & development · 2023Review
- Multimodal characterization of murine gastruloid development.Cell stem cell · 2023Article
- Stay on the road: from germ cell specification to gonadal colonization in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Oct4 dependent chromatin activation is required for chicken primordial germ cell migration.Stem cell reviews and reports · 2022Article
- BMP4 drives primed to naïve transition through PGC-like state.Nature communications · 2022Article
- Avian Embryonic Culture: A Perspective ofFrontiers in physiology · 2022Review
- Divergent roles for KLF4 and TFCP2L1 in naive ground state pluripotency and human primordial germ cell development.Stem cell research · 2021Article
- To Be or Not to Be a Germ Cell: The Extragonadal Germ Cell Tumor Paradigm.International journal of molecular sciences · 2021Review
- All models are wrong, but some are useful: Establishing standards for stem cell-based embryo models.Stem cell reports · 2021Review
- Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation.American journal of stem cells · 2021Article
- Expression and possible roles of extracellular signal-related kinases 1-2 (ERK1-2) in mouse primordial germ cell development.The Journal of reproduction and development · 2020Article
- An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure.Stem cell reports · 2020Article
- Defined conditions for propagation and manipulation of mouse embryonic stem cells.Development (Cambridge, England) · 2019Article
- Regulation of Kit Expression in Early Mouse Embryos and ES Cells.Stem cells (Dayton, Ohio) · 2019Article
- Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency.Development (Cambridge, England) · 2018Article
- Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.Cell reports · 2018Article
- Identification of KLF9 and BCL3 as transcription factors that enhance reprogramming of primordial germ cells.PloS one · 2018Article
- Distinct requirements for energy metabolism in mouse primordial germ cells and their reprogramming to embryonic germ cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Mammalian primordial germ cells (PGCs) are unipotent progenitors of the gametes. Nonetheless, they can give rise directly to pluripotent stem cells in vitro or during teratocarcinogenesis. This conversion is inconsistent, however, and has been difficult to study. Here, we delineate requirements for efficient resetting of pluripotency in culture. We demonstrate that in defined conditions, routinely 20% of PGCs become EG cells. Conversion can occur from the earliest specified PGCs. The entire process can be tracked from single cells. It is driven by leukemia inhibitory factor (LIF) and the downstream transcription factor STAT3. In contrast, LIF signaling is not required during germ cell ontogeny. We surmise that ectopic LIF/STAT3 stimulation reconstructs latent pluripotency and self-renewal. Notably, STAT3 targets are significantly upregulated in germ cell tumors, suggesting that dysregulation of this pathway may underlie teratocarcinogenesis. These findings demonstrate that EG cell formation is a robust experimental system for exploring mechanisms involved in reprogramming and cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.