ArticleTheranostics2013
Label-free luminescent mesoporous silica nanoparticles for imaging and drug delivery.
Article in Theranostics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 93 citations in OpenAlex.
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- Tumor diagnosis using carbon-based quantum dots: Detection based on the hallmarks of cancer.Bioactive materials · 2024Review
- Nanostructured N/S doped carbon dots/mesoporous silica nanoparticles and PVA composite hydrogel fabrication for anti-microbial and anti-biofilm application.International journal of pharmaceutics: X · 2023Article
- Effects of Methoxyfenozide-Loaded Fluorescent Mesoporous Silica Nanoparticles onInternational journal of molecular sciences · 2022Article
- Carbonized paramagnetic complexes of Mn (II) as contrast agents for precise magnetic resonance imaging of sub-millimeter-sized orthotopic tumors.Nature communications · 2022Article
- Single-step acid-catalyzed synthesis of luminescent colloidal organosilica nanobeads.Nano convergence · 2022Article
- Correlation of Secondary Particle Number with the Debye-Hückel Parameter for Thickening Mesoporous Silica Shells Formed on Spherical Cores.ACS omega · 2021Article
- An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine.Pharmaceutics · 2021Review
- Mesoporous Silica Nanoparticles in Bioimaging.Materials (Basel, Switzerland) · 2020Review
- Classification, Synthesis, and Application of Luminescent Silica Nanoparticles: a Review.Nanoscale research letters · 2019Review
- Luminescent Mesoporous Silica Nanohybrid Based on Drug Derivative Terbium Complex.Materials (Basel, Switzerland) · 2019Article
- Luminescent mesoporous nanorods as photocatalytic enzyme-like peroxidase surrogates.Chemical science · 2018Article
- Microfluidic preparation of monodisperse polymeric microspheres coated with silica nanoparticles.Scientific reports · 2018Article
- Regeneration of Arrayed Gold Microelectrodes Equipped for a Real-Time Cell Analyzer.Journal of visualized experiments : JoVE · 2018Article
- Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging.Advanced materials (Deerfield Beach, Fla.) · 2014Article
- Mesoporous silica nanoparticles in target drug delivery system: A review.International journal of pharmaceutical investigationReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
We report herein a straightforward and label-free approach to prepare luminescent mesoporous silica nanoparticles. We found that calcination at 400 °C can grant mesoporous organosilica nanoparticles with strong fluorescence of great photo- and chemical stability. The luminescence is found to originate from the carbon dots generated from the calcination, rather than the defects in the silica matrix as was believed previously. The calcination does not impact the particles' abilities to load drugs and conjugate to biomolecules. In a proof-of-concept study, we demonstrated that doxorubicin (Dox) can be efficiently encapsulated into these fluorescent mesoporous silica nanoparticles. After coupled to c(RGDyK), the nanoconjugates can efficiently home to tumors through interactions with integrin αvβ3 overexpressed on the tumor vasculature. This calcination-induced luminescence is expected to find wide applications in silica-based drug delivery, nanoparticle coating, and immunofluorescence imaging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.