Evidence map›Paper›PMID 24052690›Full record

ArticleMacromolecular chemistry and physics2013

Clickable Poly(ethylene glycol)-Microsphere-Based Cell Scaffolds.

Peter K Nguyen, Christopher G Snyder, Jason D Shields, Amanda W Smith, Donald L Elbert

Abstract read
In one paragraph

Article in Macromolecular chemistry and physics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Peter K NguyenDepartment of Biomedical Engineering, Campus Box 1907, One Brookings Dr., Washington University, St. Louis, MO 63130, USA.
Christopher G Snyder
Jason D Shields
Amanda W Smith
Donald L Elbert
Washington University in St. Louis · US

Funding

Development of materials to release bioactive lipidsR01HL085364 · NHLBI · WASHINGTON UNIVERSITY · PI ELBERT, DONALD L · 2006 to 2010
$1.8M
NHLBI NIH HHS R01 HL085364
6 · The paper itself

Abstract

Clickable poly(ethylene glycol) (PEG) derivatives are used with two sequential aqueous two-phase systems to produce microsphere-based scaffolds for cell encapsulation. In the first step, sodium sulfate causes phase separation of the clickable PEG precursors and is followed by rapid geleation to form microspheres in the absence of organic solvent or surfactant. The microspheres are washed and then deswollen in dextran solutions in the presence of cells, producing tightly packed scaffolds that can be easily handled while also maintaining porosity. Endothelial cells included during microsphere scaffold formation show high viability. The clickable PEG-microsphere-based cell scaffolds open up new avenues for manipulating scaffold architecture as compared with simple bulk hydrogels.

Indexed as

biomaterialsclick chemistryhydrogelsmicrosphere scaffoldspoly(ethylene glycol)

Identifiers

PMID24052690
PMCPMC3774304
OpenAlexW2057929333

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.