ArticleBulletin of the World Health Organization2013
Use of data from registered clinical trials to identify gaps in health research and development.
Article in Bulletin of the World Health Organization, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- A snapshot of selected neglected tropical disease research using the World Health Organization International Clinical Trials Registry Platform database, 1999-2023.PLoS neglected tropical diseases · 2026Article
- The usefulness of orthopedic shoulder surgery randomized controlled trials: are they meeting the key criteria?JSES reviews, reports, and techniques · 2025Article
- Human papillomavirus (HPV) trials: A cross-sectional analysis of clinical trials registries.Human vaccines & immunotherapeutics · 2024Article
- Characterization of clinical trials in Ecuador and their association with disease burden: Are there research gaps?Journal of family medicine and primary care · 2024Review
- Global Equity in Clinical Trials: An ASCO Policy Statement.JCO global oncology · 2024Article
- Iran's research prioritization: Are we meeting the goals? A study based on clinical trial registry data.PloS one · 2024Article
- Article
- Secondary analysis of data from a core outcome set for burns demonstrated the need for involvement of lower income countries.Journal of clinical epidemiology · 2022Article
- Discrepancies between FDA documents and ClinicalTrials.gov for Orphan Drug-related clinical trial data.PLOS global public health · 2022Article
- Prioritising health research in KwaZulu-Natal: has the research conducted met the research needs?Health research policy and systems · 2020Article
- A comparison between health research output and burden of disease in Arab countries: evidence from Palestine.Health research policy and systems · 2018Article
- Adherence to clinical trial registration in countries of Latin America and the Caribbean, 2015.Revista panamericana de salud publica = Pan American journal of public health · 2018Article
- Action plan for optimizing the design of clinical trials in chronic kidney disease.Kidney international supplements · 2017Review
- Automatic classification of registered clinical trials towards the Global Burden of Diseases taxonomy of diseases and injuries.BMC bioinformatics · 2016Article
- Why Most Clinical Research Is Not Useful.PLoS medicine · 2016Article
- The evolution in registration of clinical trials: a chronicle of the historical calls and current initiatives promoting transparency.European journal of clinical pharmacology · 2015Review
- Article
- Article
- Poverty-related and neglected diseases - an economic and epidemiological analysis of poverty relatedness and neglect in research and development.Global health action · 2015Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo explore what can be learnt about the current composition of the "global landscape" of health research and development (R&D) from data on the World Health Organization's International Clinical Trials Registry Platform (ICTRP).
methodsA random 5% sample of the records of clinical trials that were registered as interventional and actively recruiting was taken from the ICTRP database.
findingsOverall, 2381 records of trials were investigated. Analysis of these records indicated that, for every million disability-adjusted life years (DALYs) caused by communicable, maternal, perinatal and nutritional conditions, by noncommunicable diseases, or by injuries, the ICTRP database contained an estimated 7.4, 52.4 and 6.0 trials in which these causes of burden of disease were being investigated, respectively. For every million DALYs in high-income, upper-middle-income, lower-middle-income and low-income countries, an estimated 292.7, 13.4, 3.0 and 0.8 registered trials, respectively, were recruiting in such countries.
conclusionThe ICTRP constitutes a valuable resource for assessing the global distribution of clinical trials and for informing policy development for health R&D. Populations in lower-income countries receive much less attention, in terms of clinical trial research, than populations in higher-income countries.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.