Trial reportVascular medicine (London, England)2013
n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial.
Trial report in Vascular medicine (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and Inflammation II
The Use of Fish Oil to Reduce Inflammation Caused by a Peripheral Vascular Intervention
THE OMEGA-SPM-DOSE and OMEGA-SPM-PAD: Specialized Pro-Resolving Mediators in Patients With Peripheral Artery Disease
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Omega-3 fatty acids for intermittent claudication.The Cochrane database of systematic reviews · 2024Pooled it
- Omega-3 Polyunsaturated Fatty Acids are not associated with Peripheral Artery Disease in a Meta-Analysis from the Multi-Ethnic Study of Atherosclerosis and Atherosclerosis Risk in Communities Study Cohorts.The Journal of nutrition · 2024Pooled it
- Fish Oil Increases Specialized Pro-resolving Lipid Mediators in PAD (The OMEGA-PAD II Trial).The Journal of surgical research · 2019Trial
- Predictors of change in omega-3 index with fish oil supplementation in peripheral artery disease.The Journal of surgical research · 2017Trial
- Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial).Journal of the American Heart Association · 2015Trial
- Relationship between the omega-3 index and specialized pro-resolving lipid mediators in patients with peripheral arterial disease taking fish oil supplements.Journal of clinical lipidologyTrial
- Plasma Gut Microbe-Derived Metabolites Associated with Peripheral Artery Disease and Major Adverse Cardiac Events.Microorganisms · 2022Article
- New Insights on the Effects of Dietary Omega-3 Fatty Acids on Impaired Skin Healing in Diabetes and Chronic Venous Leg Ulcers.Foods (Basel, Switzerland) · 2021Review
- Leptinemia is Associated With Peripheral Artery Disease.The Journal of surgical research · 2019Article
- Aspirin-triggered proresolving mediators stimulate resolution in cancer.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Resolvins suppress tumor growth and enhance cancer therapy.The Journal of experimental medicine · 2018Article
- Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans.Journal of the American Heart Association · 2016Observational
- Advancing beyond the "heart-healthy diet" for peripheral arterial disease.Journal of vascular surgery · 2015Review
- Relationship between kidney disease and endothelial function in peripheral artery disease.Journal of vascular surgery · 2014Article
- Clinical correlates of red blood cell omega-3 fatty acid content in male veterans with peripheral arterial disease.Journal of vascular surgery · 2014Observational
- Ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery in clinical research.Journal of visualized experiments : JoVE · 2014Article
- Nutritional profile of older adults with chronic venous leg ulcers: a pilot study.Geriatric nursing (New York, N.Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Despite current consensus guidelines recommending intensive cardiovascular risk factor management for peripheral artery disease (PAD), patients suffering from PAD continue to experience significant morbidity and mortality. This excess morbid burden is at least partially related to impaired vascular function and systemic inflammation. Interventions bridging this gap are critical. Dietary supplementation of n-3 polyunsaturated fatty acids (n-3 PUFA) has been shown to improve endothelial function and reduce inflammation in different cohorts, as well as to decrease cardiovascular events in secondary prevention trials in patients with coronary artery disease. Their effects in the PAD population are, however, less well understood. The OMEGA-PAD trial is a double-blinded, randomized, placebo-controlled trial that examines the impact of a high-dose, short-duration dietary oral supplementation of n-3 PUFA on vascular function and inflammation in patients with established PAD. The purpose of this article is to provide a detailed description of the design and methods of the OMEGA-PAD trial, and a summary of baseline characteristics of the cohort.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.