ArticleJournal of nephrology
Tubular injury marker netrin-1 is elevated early in experimental diabetes.
Article in Journal of nephrology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Urinary and circulatory netrin-1 as biomarker in diabetes and its related complications: a systematic review and meta-analysis.Endocrine · 2024Pooled it
- Utility of urinary netrin-1 levels in patients with type 2 diabetic nephropathy and its correlation with renal function.BMC endocrine disorders · 2025Article
- Transient renal tubular injury among children and adolescents during diabetic ketoacidosis: severity, renal perfusion, and urinary netrin- 1 interplay.European journal of pediatrics · 2025Article
- Early renal structural changes and potential biomarkers in diabetic nephropathy.Frontiers in physiology · 2022Review
- Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus.Biochemistry and biophysics reports · 2021Article
- Is Urinary Netrin-1 a Good Marker of Tubular Damage in Preterm Newborns?Journal of clinical medicine · 2021Article
- Urinary netrin-1 concentration in healthy full-term newborns.Archives of medical science : AMS · 2021Article
- Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes.Frontiers in endocrinology · 2018Article
- Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications.Journal of diabetes research · 2018Review
- Neuron-derived netrin-1 and netrin-4 proteins are additional effective targets in diabetic retinopathy beyond VEGF.International journal of clinical and experimental pathology · 2017Article
- Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes.Journal of clinical laboratory analysis · 2016Article
- Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children.Journal of clinical research in pediatric endocrinology · 2016Article
- Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes.Journal of nephrology · 2014Article
- Guidance cue netrin-1 and the regulation of inflammation in acute and chronic kidney disease.Mediators of inflammation · 2014Review
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Authors and funding
4 authors.
Funding
Abstract
backgroundNetrin-1 was recently identified as an early diagnostic biomarker of acute kidney injury. However, its usefulness for early diagnosis of chronic kidney disease (CKD) is unknown. The current study evaluated whether these proteins are increased in urine from experimental animals with diabetes.
methodsThe current study evaluated whether netrin-1 is increased in urine from diabetic rats and mice, and whether netrin-1 correlated with development of nephropathy.
resultsIn rats, urinary netrin-1 excretion was significantly (p<0.001) higher in the diabetic group at 4 and 10 weeks after induction of diabetes as compared with the control group. Similarly, netrin-1 was increased significantly (p<0.001) in urine from hypertensive rats at 4 weeks as compared with controls. Likewise, urinary albumin excretion rates were increased in diabetic rats at 4 and 10 weeks as compared with controls and were increased in hypertensive rats at 4 weeks. Consistent with the diabetic model in rats, netrin-1 excretion was also increased early in diabetic mice's urine, and peak levels correlated with disease severity.
conclusionNetrin-1 can be detected in urine from diabetic and hypertensive rats and may serve as a useful early diagnostic biomarker for development of CKD.
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