ReviewNature reviews. Immunology2013
Thymus involution and regeneration: two sides of the same coin?
Review in Nature reviews. Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed.
- Association Between Prognostic Nutritional Index and Clinical Outcomes After Percutaneous Coronary Intervention in Elderly Patients with Chronic Total Occlusion.Journal of cardiovascular development and disease · 2026Article
- Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean.Journal of advanced research · 2026Article
- Selective disruption of RORγt-CBFβ interaction by IMU-935 prevents RORγt-dependent Th17 autoimmunity but not thymocyte development.The Journal of clinical investigation · 2026Article
- Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.Frontiers in immunology · 2026Article
- Ferroptosis mediated by the IDO1/Kyn/AhR pathway triggers acute thymic involution in sepsis.Cell death & disease · 2025Article
- A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice.Science immunology · 2025Article
- Review
- Understanding vertebrate immunity through comparative immunology.Nature reviews. Immunology · 2025Review
- Investigation of the mechanism of hypertension caused by BTKi in the treatment of hematologic diseases.Frontiers in pharmacology · 2025Review
- Neural regulation of the thymus: past, current, and future perspectives.Frontiers in immunology · 2025Review
- Review
- Age-Related Thymic Involution.Advances in experimental medicine and biology · 2025Review
- Reimplantation of Thymus at the First Superior Cavo-Pulmonary Anastomosis and Its Outcome.Cureus · 2024Article
- Age-related epithelial defects limit thymic function and regeneration.Nature immunology · 2024Article
- Thymic epithelial organoids mediate T-cell development.Development (Cambridge, England) · 2024Article
- A cross-sectional National Health and Nutrition Examination survey-based study of the association between systemic immune-inflammation index and blood urea nitrogen levels in United States adolescents.Scientific reports · 2024Article
- Dynamic Changes in Lymphocyte Populations Establish Zebrafish as a Thymic Involution Model.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.Frontiers in immunology · 2024Review
- Comprehensive Transcriptomic Analysis for Thymic Epithelial Cells of Aged Mice and Humans.Immune network · 2023Article
- CCK2-receptor deficiency impairs immune balance by influencing CD4Experimental biology and medicine (Maywood, N.J.) · 2023Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In vertebrates, the thymus is the main site of T cell development. The thymus reaches its maximum output during adolescence, after which it shrinks and generates fewer and fewer T cells. Physiological age-related involution of the thymus and failure to recover after injury are associated with impaired cellular immunity; hence, there is considerable interest in developing strategies to combat these deficiencies. In this Opinion article, we briefly review the phylogenetic and ontogenetic hallmarks of thymus development and function, and we discuss experimental models of impaired thymopoiesis and the molecular mechanisms of thymopoietic recovery. At each stage of the discussion we highlight the major gaps in our current knowledge.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.