Evidence map›Paper›PMID 24052086›Full record

ReviewNature reviews. Genetics2013

Recent human adaptation: genomic approaches, interpretation and insights.

Laura B Scheinfeldt, Sarah A Tishkoff

Abstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed.

  1. CircadianiScience · 2026
    Article
  2. Review
  3. Selection scans and downstream analysis with selscan.Human population genetics and genomics · 2026
    Article
  4. Article
  5. Selection scans and downstream analysis with selscan.bioRxiv : the preprint server for biology · 2025
    Article
  6. Unmet needs in autoimmune liver diseases.Current opinion in immunology · 2025
    Review
  7. bioRxiv : the preprint server for biology · 2025
    Article
  8. Parallels and discrepancies between non-native species introductions and human migration.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  9. Article
  10. Article
  11. Pleiotropic Effects ofInternational journal of molecular sciences · 2022
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Laura B Scheinfeldt1] Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. [2] Coriell Institute for Medical Research, Camden, New Jersey 08103, USA.
Sarah A Tishkoff

Funding

African Odyssey: An Integrative Genomics Analysis of Complex Physiologic TraitsDP1OD006445 · OD · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2009 to 2011
$2.4M
African Odyssey: An Integrative Genomics Analysis of Complex Physiologic TraitsDP1ES022577 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI TISHKOFF, SARAH ANNE · 2012 to 2013
$1.6M
Variation at Malaria Resistance Genes in AfricansR01GM076637 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI TISHKOFF, SARAH ANNE · 2006 to 2009
$1.2M
NIEHS NIH HHS DP1 ES022577NIGMS NIH HHS R01 GM076637NIGMS NIH HHS R01GM076637NIH HHS DP1 OD006445NIH HHS DP1OD0644S
6 · The paper itself

Abstract

The recent availability of genomic data has spurred many genome-wide studies of human adaptation in different populations worldwide. Such studies have provided insights into novel candidate genes and pathways that are putatively involved in adaptation to different environments, diets and disease prevalence. However, much work is needed to translate these results into candidate adaptive variants that are biologically interpretable. In this Review, we discuss methods that may help to identify true biological signals of selection and studies that incorporate complementary phenotypic and functional data. We conclude with recommendations for future studies that focus on opportunities to use integrative genomics methodologies in human adaptation studies.

Indexed as

Adaptation, PhysiologicalGenetic VariationGenome, HumanGenomicsHumansMutationPhenotypeSelection, Genetic

Identifiers

PMID24052086
PMCPMC4882605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.