ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2014
Survival and prognostic factors in non-small cell lung cancer patients with spinal bone metastases: a retrospective analysis of 303 patients.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- German radiation oncology's next generation: a web-based survey of young biologists, medical physicists, and physicians-from problems to solutions.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2024Article
- Development and validation of nomograms to predict early death in non-small cell lung cancer patients with brain metastasis: a retrospective study in the SEER database.Translational cancer research · 2023Article
- Association between Overall Survival and Activities of Daily Living in Patients with Spinal Bone Metastases.Healthcare (Basel, Switzerland) · 2022Article
- A narrative review of evolving roles of radiotherapy in advanced non-small cell lung cancer: from palliative care to active player.Translational lung cancer research · 2020Review
- Clinical features and prognostic factors in patients with bone metastases from non-small cell lung cancer.The Journal of international medical research · 2020Observational
- Surgical Treatment Outcomes of Spinal Metastases of Nasopharyngeal Carcinoma: The First Report of 30 Patients from a Single Center.Cancer management and research · 2020Article
- Clinical outcome for small cell lung cancer patients with bone metastases at the time of diagnosis.Journal of bone oncology · 2019Article
- [Comparison of the Survival Time in the Non-small Cell Lung Cancer Patients with Different Organ Metastasis].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2019Article
- Situation of young radiation oncologists, medical physicists and radiation biologists in German-speaking countries : Results from a web-based survey of the Young DEGRO working group.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2016Article
- Survival and prognostic factors in patients with stable and unstable spinal bone metastases from solid tumors: a retrospective analysis of 915 cases.BMC cancer · 2016Article
- Prognostic factors for survival of women with unstable spinal bone metastases from breast cancer.Radiation oncology (London, England) · 2015Article
- M1 stage subdivision and treatment outcome of patients with bone-only metastasis of nasopharyngeal carcinoma.The oncologist · 2015Article
- Clinicopathologic characteristics and survival of patients with bone metastasis in Yazd, Iran: a cross-sectional retrospective study.Medicine · 2014Article
- Stability of spinal bone metastases in breast cancer after radiotherapy: a retrospective analysis of 157 cases.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2014Article
- Quality of life, fatigue and local response of patients with unstable spinal bone metastases under radiation therapy--a prospective trial.Radiation oncology (London, England) · 2014Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeFor palliative care of spinal bone metastases, stability assessment is of crucial importance. Pathological fractures, instability-related patient immobility and the extent of bone metastasis have been reported to affect patient outcome and these parameters have therefore been used for treatment stratification. We report on stability-dependent fracture and survival rates in over 300 non-small cell lung cancer (NSCLC) patients. MATERIALS AND
methodsData from 303 patients with 868 osteolytic metastases treated with radiotherapy (RT) between 2000 and 2012 were evaluated retrospectively.
resultsIn NSCLC patients with bone metastases only, the retrospective 6- and 12-month overall survival (OS) rates were 76.7 and 47.2%, respectively. In patients with additional non-bone distant metastases, these values were 60.0 and 34.0%, respectively. Survival rates were significantly lower in patients with multiple bone metastases and in those suffering pathological fractures (p=0.017). No significant impact of histological type, location of spinal lesions or treatment regime was detected. Furthermore, stability assessment revealed no influence of vertebral column stability on patient outcome (p=0.739).
conclusionOur analysis demonstrated a correlation between the pathological fractures of bone lesions, the number of bone metastases, additional distant metastases and survival. The results offer a rationale for future prospective investigations.
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