ArticleMolecules (Basel, Switzerland)2013
Combined effects of green tea extracts, green tea polyphenols or epigallocatechin gallate with acarbose on inhibition against α-amylase and α-glucosidase in vitro.
Article in Molecules (Basel, Switzerland), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 102 citations in OpenAlex.
- Oxidative stress and food supplementation with antioxidants in therapy dogs.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2017Trial
- Green tea extract decreases starch digestion and absorption from a test meal in humans: a randomized, placebo-controlled crossover study.Scientific reports · 2015Trial
- Antagonistic Polyphenol Interactions Underlie the α-Glucosidase Inhibitory Activity of Keemun Black Tea.Foods (Basel, Switzerland) · 2026Article
- Modern Approaches to Diabetes: The Role of Phytochemicals in Targeting Molecular Receptors.Current topics in medicinal chemistry · 2025Review
- The Heating Under Micro Variable Pressure (HUMVP) Process to Decrease the Level of Saponin in Quinoa: Evidence of the Antioxidation and the Inhibitory Activity of α-Amylase and α-Glucosidase.Foods (Basel, Switzerland) · 2024Article
- Phytochemical Analysis, Biological Activities, and Docking of Phenolics from Shoot Cultures ofMolecules (Basel, Switzerland) · 2024Article
- Evaluation of Biological Activities of Twenty Flavones and In Silico Docking Study.Molecules (Basel, Switzerland) · 2023Article
- Flavonoid Constituents and Alpha-Glucosidase Inhibition ofMolecules (Basel, Switzerland) · 2022Article
- Apple Fibers as Carriers of Blackberry Juice Polyphenols: Development of Natural Functional Food Additives.Molecules (Basel, Switzerland) · 2022Article
- Structural changes and molecular mechanism study on the inhibitory activity of epigallocatechin against α-glucosidase and α-amylase.Frontiers in nutrition · 2022Article
- Flavonoids as Human Intestinal α-Glucosidase Inhibitors.Foods (Basel, Switzerland) · 2021Article
- Pharmaceutical Drugs and Natural Therapeutic Products for the Treatment of Type 2 Diabetes Mellitus.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Diabetes medications as potential calorie restriction mimetics-a focus on the alpha-glucosidase inhibitor acarbose.GeroScience · 2021Article
- Phytochemical properties of black tea (Journal of food science and technology · 2020Article
- Review
- Insoluble-Bound Polyphenols Released from Guarana Powder: Inhibition of Alpha-Glucosidase and Proanthocyanidin Profile.Molecules (Basel, Switzerland) · 2020Article
- Antioxidant Activity, Enzyme Inhibition Potentials, and Phytochemical Profiling ofInternational journal of food science · 2020Article
- Optimizing synchronous extraction and antioxidant activity evaluation of polyphenols and polysaccharides from Ya'an Tibetan tea (Food science & nutrition · 2020Article
- Utilizing the Combination of Binding Kinetics and Micro-Pharmacokinetics Link in Vitro α-Glucosidase Inhibition to in Vivo Target Occupancy.Biomolecules · 2019Article
- Effects and Mechanisms of Tea for the Prevention and Management of Diabetes Mellitus and Diabetic Complications: An Updated Review.Antioxidants (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Green tea, green tea polyphenols and epigallocatechin gallate (EGCG) are confirmed to have beneficial effects in the treatment of diabetes mellitus, and a possible mechanism can be ascribed to their inhibitory effect against α-amylase and α-glucosidase in the digestive tract. In this paper, we first investigated the combined inhibitory effect of green tea extracts, green tea polyphenols or EGCG with acarbose on α-amylase and α-glucosidase in vitro. Our results indicated that the interaction between green tea extracts (green tea polyphenols or EGCG) and acarbose was complicated. The combination of green tea extracts, green tea polyphenols or EGCG with acarbose had a synergistic effect on α-amylase and α-glucosidase at low concentrations and the combined effect turned out to be antagonistic at high concentrations according to the Combination Index (CI) values. These findings not only provided some significant quantitative values, but also provide some valuable implications for the combined use of acarbose and GTE (GTP or EGCG) in the treatment of diabetes mellitus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.