ArticleThe Journal of clinical investigation2013
Zinc, insulin, and the liver: a ménage à trois.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Role of Zinc and Magnesium in Glycemic Status Among the Saudi Population.International journal of general medicine · 2025Article
- Formulation of protein-loaded nanoparticles via freeze-drying.Drug delivery and translational research · 2024Article
- Coordination chemistry suggests that independently observed benefits of metformin and ZnBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Article
- Quantitative imaging approaches to understanding biological processing of metal ions.Current opinion in chemical biology · 2022Review
- Zinc Coordination Compounds with Benzimidazole Derivatives: Synthesis, Structure, Antimicrobial Activity and Potential Anticancer Application.International journal of molecular sciences · 2022Article
- Review
- Inside the Insulin Secretory Granule.Metabolites · 2021Review
- Divergent evolution and purifying selection of the Type 2 diabetes gene sequences in Drosophila: a phylogenomic study.Genetica · 2020Article
- Interrogating Intracellular Zinc Chemistry with a Long Stokes Shift Zinc Probe ZincBY-4.Journal of the American Chemical Society · 2019Article
- Pancreatic human islets and insulin-producing cells derived from embryonic stem cells are rapidly identified by a newly developed Dithizone.Scientific reports · 2019Article
- ZnO nanoparticles affect nutrient transport in an in vitro model of the small intestine.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2019Article
- Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology.Metallomics : integrated biometal science · 2019Review
- Structure-based stabilization of insulin as a therapeutic protein assembly via enhanced aromatic-aromatic interactions.The Journal of biological chemistry · 2018Article
- ZnO nanoparticles affect intestinal function in an in vitro model.Food & function · 2018Article
- Effects of proteinate complex zinc on growth performance, hepatic and splenic trace elements concentrations, antioxidative function and immune functions in weaned piglets.Asian-Australasian journal of animal sciences · 2017Article
- The Functions of Metallothionein and ZIP and ZnT Transporters: An Overview and Perspective.International journal of molecular sciences · 2016Review
- Imaging trace element distributions in single organelles and subcellular features.Scientific reports · 2016Article
- Comparative Evaluation of Two Venous Sampling Techniques for the Assessment of Pancreatic Insulin and Zinc Release upon Glucose Challenge.Journal of diabetes research · 2015Article
- Biological consequences of zinc deficiency in the pathomechanisms of selected diseases.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
Corrections and comments
- Comment on
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin and Zn2+ enjoy a multivalent relationship. Zn2+ binds insulin in pancreatic β cells to form crystalline aggregates in dense core vesicles (DCVs), which are released in response to physiological signals such as increased blood glucose. This transition metal is an essential cofactor in insulin-degrading enzyme and several key Zn2+ finger transcription factors that are required for β cell development and insulin gene expression. Studies are increasingly revealing that fluctuations in Zn2+ concentration can mediate signaling events, including dynamic roles that extend beyond that of a static structural or catalytic cofactor. In this issue of the JCI, Tamaki et al. propose an additional function for Zn2+ in relation to insulin: regulation of insulin clearance from the bloodstream.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.