ArticleDevelopmental biology2013
Ecdysone signaling at metamorphosis triggers apoptosis of Drosophila abdominal muscles.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 59 citations in OpenAlex.
- Independent roles of autophagy and apoptosis in post-apocrine-secretion cell death of salivary glands during Drosophila metamorphosis.Scientific reports · 2026Article
- Ecdysone regulates phagocytic cell fate of epithelial cells in developing Drosophila eggs.The Journal of cell biology · 2025Article
- Dual-purpose dynamics emerge from a heterogeneous cell population in Drosophila metamorphosis.PLoS computational biology · 2025Article
- Astrocyte-dependent local neurite pruning in Beat-Va neurons.The Journal of cell biology · 2025Article
- Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025Article
- Reduction of endocytosis and EGFR signaling is associated with the switch from isolated to clustered apoptosis during epithelial tissue remodeling in Drosophila.PLoS biology · 2024Article
- Muscle degeneration in aging Drosophila flies: the role of mechanical stress.Skeletal muscle · 2024Article
- Inter-organ steroid hormone signaling promotes myoblast fusion via direct transcriptional regulation of a single key effector gene.Current biology : CB · 2024Article
- Distinct developmental patterns in Anopheles stephensi organ systems.Developmental biology · 2024Article
- Understanding Developmental Cell Death UsingCells · 2024Review
- 5mC modification orchestrates choriogenesis and fertilization by preventing prolonged ftz-f1 expression.Nature communications · 2023Article
- Macrophage subpopulation identity inFrontiers in immunology · 2023Article
- Insights and perspectives on the enigmatic alary muscles of arthropods.Frontiers in cell and developmental biology · 2023Review
- Polyploidy in development and tumor models in Drosophila.Seminars in cancer biology · 2022Review
- Integration of proteomic and genetic approaches to assess developmental muscle atrophy.The Journal of experimental biology · 2021Article
- Programmed cell death reshapes the central nervous system during metamorphosis in insects.Current opinion in insect science · 2021Review
- High-resolution analysis of differential gene expression during skeletal muscle atrophy and programmed cell death.Physiological genomics · 2020Article
- Long-term in vivo imaging of Drosophila larvae.Nature protocols · 2020Article
- Drosophila metamorphosis involves hemocyte mediated macroendocytosis and efferocytosis.The International journal of developmental biology · 2020Article
- Ecdysone controlled cell and tissue deletion.Cell death and differentiation · 2020Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
Abstract
One of the most dramatic examples of programmed cell death occurs during Drosophila metamorphosis, when most of the larval tissues are destroyed in a process termed histolysis. Much of our understanding of this process comes from analyses of salivary gland and midgut cell death. In contrast, relatively little is known about the degradation of the larval musculature. Here, we analyze the programmed destruction of the abdominal dorsal exterior oblique muscle (DEOM) which occurs during the first 24h of metamorphosis. We find that ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. Furthermore, we show that the orphan nuclear receptor FTZ-F1, opposed by another nuclear receptor, HR39, plays a critical role in the timing of DEOM histolysis. Finally, we show that unlike the histolysis of salivary gland and midgut, abdominal muscle death occurs by apoptosis, and does not require autophagy. Thus, there is no set rule as to the role of autophagy and apoptosis during Drosophila histolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.