Evidence map›Paper›PMID 24051180›Full record

ArticleFree radical biology & medicine2013

Evaluation of long-term vitamin E insufficiency or excess on bone mass, density, and microarchitecture in rodents.

Urszula T Iwaniec, Russell T Turner, Brenda J Smith, Barbara J Stoecker, Allison Rust, Bo Zhang, Vihas T Vasu, Kishorchandra Gohil, Carroll E Cross, Maret G Traber

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
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  4. Article
  5. Review
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  7. Review
  8. Associations between serum vitamin E concentration and bone mineral density in the US elderly population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  9. Vitamin E homologues α- and γ-tocopherol are not associated with bone turnover markers or bone mineral density in peri-menopausal and post-menopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016
    Article
  10. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Urszula T IwaniecSkeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA; Center for Healthy Aging Research, Oregon State University, Corvallis, OR 97331, USA.
Russell T TurnerSkeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA; Center for Healthy Aging Research, Oregon State University, Corvallis, OR 97331, USA.
Brenda J SmithDepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Barbara J StoeckerDepartment of Nutritional Sciences, College of Human Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
Allison RustSkeletal Biology Laboratory, Oregon State University, Corvallis, OR 97331, USA.
Bo ZhangBiostatistics Core, School of Biological and Population Health Sciences, Oregon State University, Corvallis, OR 97331, USA.
Vihas T VasuDepartment of Internal Medicine, Genome and Biomedical Sciences Facility, University of California at Davis, Davis, CA 95616, USA.
Kishorchandra GohilDepartment of Internal Medicine, Genome and Biomedical Sciences Facility, University of California at Davis, Davis, CA 95616, USA.
Carroll E CrossDepartment of Internal Medicine, Genome and Biomedical Sciences Facility, University of California at Davis, Davis, CA 95616, USA.
Maret G TraberLinus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA. Electronic address: maret.traber@oregonstate.edu.
Oregon State University · USUniversity of California, Davis · USOklahoma State University · US

Funding

Vitamin E metabolism and lung toxicologyR01ES011985 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI CROSS, CARROLL E · 2004 to 2006
$942k
NIEHS NIH HHS ES011985NIEHS NIH HHS R01 ES011985
6 · The paper itself

Abstract

High dietary α-tocopherol levels reportedly result in osteopenia in growing rats, whereas α-tocopherol deficiency in α-tocopherol transfer protein-knockout (α-TTP-KO) mice results in increased cancellous bone mass. Because osteoporosis is a disease associated primarily with aging, we hypothesized that age-related bone loss would be attenuated in α-TTP-KO mice. Cancellous and cortical bone mass and microarchitecture were assessed using dual-energy X-ray absorptiometry and micro-computed tomography in 2-year-old α-TTP-KO and wild-type (WT) male and female mice fed dl-α-tocopherol acetate. In contrast to our expectations, differences in cancellous bone were not detected between WT and α-TTP-KO mice of either gender, and α-TTP-KO males had lower (p<0.05) cortical bone mass than WT males. We therefore evaluated bone mass, density, and microarchitecture in proximal femur of skeletally mature (8.5-month-old) male Sprague-Dawley rats fed diets containing low (15 IU/kg diet), adequate (75 IU/kg diet), or high (500 IU/kg diet) dl-α-tocopherol acetate for 13 weeks. Low dietary α-tocopherol did not increase bone mass. Furthermore, no reductions in cancellous or cortical bone mass were detected with high dietary α-tocopherol. Failure to detect increased bone mass in aged α-TTP-KO mice or bone changes in skeletally mature rats fed either low or high levels of α-tocopherol does not support the hypothesis that α-tocopherol has a negative impact on bone mass, density, or microarchitecture in rodents.

Indexed as

Absorptiometry, PhotonAgingalpha-TocopherolAnimalsBone DensityCarrier ProteinsDietFemaleFemurMaleMiceMice, Inbred C57BLMice, KnockoutOsteoporosisOxidative StressRatsalpha-Tocopherolalpha-tocopherol transfer proteinCarrier ProteinsReactive Oxygen SpeciesFree radicalsOsteoporosisOxidative stressRodentSkeletonVitamin E

Identifiers

PMID24051180
PMCPMC3859709
OpenAlexW2025490458

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.