ArticleJournal of neuroinflammation2013
Altered inflammatory responsiveness in serotonin transporter mutant rats.
Article in Journal of neuroinflammation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Treating myocardial infarction combined with depression via regulating M1/TNF-α/TNFR1/NF-κB.Biochemistry and biophysics reports · 2026Article
- Monoamine signaling and neuroinflammation: mechanistic connections and implications for neuropsychiatric disorders.Frontiers in immunology · 2025Review
- Hydroxychloroquine Increased Anxiety-Like Behaviors and Disrupted the Expression of Some Related Genes in the Mouse Brain.Frontiers in pharmacology · 2021Article
- Differential Neuroinflammatory Response in Male and Female Mice: A Role for BDNF.Frontiers in molecular neuroscience · 2019Article
- Vitamin K2 Prevents Lymphoma in Drosophila.Scientific reports · 2017Article
- Low-dose lipopolysaccharide (LPS) inhibits aggressive and augments depressive behaviours in a chronic mild stress model in mice.Journal of neuroinflammation · 2016Article
- Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging.Journal of neuroinflammation · 2015Article
- ROS and brain diseases: the good, the bad, and the ugly.Oxidative medicine and cellular longevity · 2013Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGrowing evidence suggests that alterations of the inflammatory/immune system contribute to the pathogenesis of depression. Indeed, depressed patients exhibit increased levels of inflammatory markers in both the periphery and the brain, and high comorbidity exists between major depression and diseases associated with inflammatory alterations. In order to characterize the link between depression and inflammation, we aimed to investigate whether an altered inflammatory system is present in a genetic model of vulnerability for depression, namely rats with partial or total deletion of the serotonin transporter (SERT) gene.
methodsWild-type, heterozygous and homozygous SERT rats were analyzed under basal condition or following a challenge with an acute injection of lipopolysaccharide (LPS) and killed 24 h or 5 days later.
resultsWe found that SERT mutant rats show altered cytokine expression in the dorsal and ventral hippocampus at basal conditions, and they also display an exacerbated cytokine response to the LPS challenge. Moreover, mutant rats exhibit differences in the expression of markers for microglia activation.
conclusionBased on these data, we suggest that basal or functional alterations of immune/inflammatory systems might contribute to the phenotype of SERT rats and to their heightened susceptibility to depressive-like behavior.
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