ArticleVirology2013
Changes in the hemagglutinin of H5N1 viruses during human infection--influence on receptor binding.
Article in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- The receptor binding properties of H5Ny influenza A viruses have evolved to bind to avian-type mucin-like O-glycans.PLoS pathogens · 2026Article
- A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors.Science (New York, N.Y.) · 2024Article
- Pathogenicity and virulence of influenza.Virulence · 2023Review
- Arbidol: The current demand, strategies, and antiviral mechanisms.Immunity, inflammation and disease · 2023Review
- Applications of Surface Plasmon Resonance and Biolayer Interferometry for Virus-Ligand Binding.Viruses · 2022Review
- Risk Assessment for Highly Pathogenic Avian Influenza A(H5N6/H5N8) Clade 2.3.4.4 Viruses.Emerging infectious diseases · 2021Article
- Genetic diversity and host adaptation of avian H5N1 influenza viruses during human infection.Emerging microbes & infections · 2019Article
- Laboratory Methods in Molecular Epidemiology: Viral Infections.Microbiology spectrum · 2018Review
- Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.Journal of virology · 2018Article
- Attenuation of highly pathogenic avian influenza A(H5N1) viruses in Indonesia following the reassortment and acquisition of genes from low pathogenicity avian influenza A virus progenitors.Emerging microbes & infections · 2018Article
- Amino Acid Substitutions HA A150V, PA A343T, and PB2 E627K Increase the Virulence of H5N6 Influenza Virus in Mice.Frontiers in microbiology · 2018Article
- A detection and quantification label-free tool to speed up downstream processing of model mucins.PloS one · 2018Article
- Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice.Virology journal · 2016Article
- Genetic Adaptation of Influenza A Viruses in Domestic Animals and Their Potential Role in Interspecies Transmission: A Literature Review.EcoHealth · 2016Review
- Structural Basis for a Switch in Receptor Binding Specificity of Two H5N1 Hemagglutinin Mutants.Cell reports · 2015Article
- Article
- The sweet spot: defining virus-sialic acid interactions.Nature reviews. Microbiology · 2014Review
- Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies.The Journal of biological chemistry · 2014Article
- Deep sequencing: becoming a critical tool in clinical virology.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Review
- Potential human adaptation mutation of influenza A(H5N1) virus, Canada.Emerging infectious diseases · 2014Article
Corrections and comments
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Authors and funding
28 authors at 5 institutions in 6 countries.
Funding
Abstract
As avian influenza A(H5N1) viruses continue to circulate in Asia and Africa, global concerns of an imminent pandemic persist. Recent experimental studies suggest that efficient transmission between humans of current H5N1 viruses only requires a few genetic changes. An essential step is alteration of the virus hemagglutinin from preferential binding to avian receptors for the recognition of human receptors present in the upper airway. We have identified receptor-binding changes which emerged during H5N1 infection of humans, due to single amino acid substitutions, Ala134Val and Ile151Phe, in the hemagglutinin. Detailed biological, receptor-binding, and structural analyses revealed reduced binding of the mutated viruses to avian-like receptors, but without commensurate increased binding to the human-like receptors investigated, possibly reflecting a receptor-binding phenotype intermediate in adaptation to more human-like characteristics. These observations emphasize that evolution in nature of avian H5N1 viruses to efficient binding of human receptors is a complex multistep process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.