ArticleBiomacromolecules2013
Peptide-functionalized oxime hydrogels with tunable mechanical properties and gelation behavior.
Article in Biomacromolecules, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Dual-Dynamic Covalently Cross-Linked Polyglycerol Hydrogels for Tumor Spheroid Culture.Biomacromolecules · 2025Article
- Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications.International journal of molecular sciences · 2024Review
- Metal-Free Click-Chemistry: A Powerful Tool for Fabricating Hydrogels for Biomedical Applications.Bioconjugate chemistry · 2024Review
- Chemical and Biological Engineering Strategies to Make and Modify Next-Generation Hydrogel Biomaterials.Matter · 2023Article
- Coumarin Dimer Is an Effective Photomechanochemical AND Gate for Small-Molecule Release.Journal of the American Chemical Society · 2023Article
- Dual-reactive hydrogels functionalizable using "Huisgen click" and "Schiff base" reactions.Turkish journal of chemistry · 2023Article
- Recent Advances in the Biomedical Applications of Functionalized Nanogels.Pharmaceutics · 2022Review
- Biomaterials via peptide assembly: Design, characterization, and application in tissue engineering.Acta biomaterialia · 2022Review
- Detecting and Monitoring Hydrogels with Medical Imaging.ACS biomaterials science & engineering · 2021Review
- Click-functionalized hydrogel design for mechanobiology investigations.Molecular systems design & engineering · 2021Article
- Photoclick Chemistry: A Bright Idea.Chemical reviews · 2021Review
- Soft Materials by Design: Unconventional Polymer Networks Give Extreme Properties.Chemical reviews · 2021Review
- A fast and versatile cross-linking strategy viaNational science review · 2021Article
- Physical and Chemical Factors Influencing the Printability of Hydrogel-based Extrusion Bioinks.Chemical reviews · 2020Review
- Hydrogel Synthesis and Stabilization via Tetrazine Click-Induced Secondary Interactions.Macromolecular rapid communications · 2020Article
- Poly(peptide): Synthesis, Structure, and Function of Peptide-Polymer Amphiphiles and Protein-like Polymers.Accounts of chemical research · 2020Article
- Ultrasound-Triggered Enzymatic Gelation.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Design and Synthesis of Chitosan-Gelatin Hybrid Hydrogels for 3D PrintableFrontiers in chemistry · 2020Article
- Hydrogels Based on Schiff Base Linkages for Biomedical Applications.Molecules (Basel, Switzerland) · 2019Review
- A Supramolecular Platform for the Introduction of Fc-Fusion Bioactive Proteins on Biomaterial Surfaces.ACS applied polymer materials · 2019Article
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Authors and funding
8 authors.
Funding
Abstract
We demonstrate the formation of polyethylene glycol (PEG) based hydrogels via oxime ligation and the photoinitiated thiol-ene 3D patterning of peptides within the hydrogel matrix postgelation. The gelation process and final mechanical strength of the hydrogels can be tuned using pH and the catalyst concentration. The time scale to reach the gel point and complete gelation can be shortened from hours to seconds using both pH and aniline catalyst, which facilitates the tuning of the storage modulus from 0.3 to over 15 kPa. Azide- and alkene-functionalized hydrogels were also synthesized, and we have shown the post gelation "click"-type Huisgen 1,3 cycloaddition and thiolene-based radical reactions for spatially defined peptide incorporation. These materials are the initial demonstration for translationally relevant hydrogel materials that possess tunable mechanical regimes attractive to soft tissue engineering and possess atom neutral chemistries attractive for post gelation patterning in the presence or absence of cells.
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Registered trials
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