ArticleEmerging infectious diseases2013
Genetic recombination and Cryptosporidium hominis virulent subtype IbA10G2.
Article in Emerging infectious diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Prevalence of human cryptosporidiosis in the Americas: systematic review and meta-analysis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Pooled it
- Variant surface protein GP60 contributes to host infectivity of Cryptosporidium parvum.Communications biology · 2024Article
- Multiple introductions and recombination events underlie the emergence of a hyper-transmissible Cryptosporidium hominis subtype in the USA.Cell host & microbe · 2023Article
- Differences in virulence and oocyst shedding profiles in lambs experimentally infected with different isolates ofCurrent research in parasitology & vector-borne diseases · 2023Article
- Cryptosporidiosis: From Prevention to Treatment, a Narrative Review.Microorganisms · 2022Review
- Evaluation of Next-Generation Sequencing Applied toPathogens (Basel, Switzerland) · 2022Article
- Global Population Genomics of Two Subspecies of Cryptosporidium hominis during 500 Years of Evolution.Molecular biology and evolution · 2022Article
- Cryptosporidiosis outbreak in Amazonia, French Guiana, 2018.PLoS neglected tropical diseases · 2022Article
- Article
- Challenges forGenes · 2021Review
- Molecular Epidemiology of Human Cryptosporidiosis in Low- and Middle-Income Countries.Clinical microbiology reviews · 2021Review
- Common occurrence of Cryptosporidium hominis in children attending day-care centers in Medellin, Colombia.Parasitology research · 2020Article
- SubtypingMicroorganisms · 2020Article
- Species and genotypes causing human cryptosporidiosis in New Zealand.Parasitology research · 2020Article
- Comparative genomic analysis of the principalPeerJ · 2020Article
- Review
- Molecular characterization of Cryptosporidium spp. from patients with diarrhoea in Lusaka, Zambia.Parasite (Paris, France) · 2020Article
- Genetic characterization reveals evidence for an association between water contamination and zoonotic transmission of aFood and waterborne parasitology · 2019Article
- Comparative genomics: how has it advanced our knowledge of cryptosporidiosis epidemiology?Parasitology research · 2019Review
- New insights into the detection and molecular characterization of Cryptosporidium with emphasis in Brazilian studies: a review.Revista do Instituto de Medicina Tropical de Sao Paulo · 2019Review
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Little is known about the emergence and spread of virulent subtypes of Cryptosporidium hominis, the predominant species responsible for human cryptosporidiosis. We conducted sequence analyses of 32 genetic loci of 53 C. hominis specimens isolated from a longitudinally followed cohort of children living in a small community. We identified by linkage disequilibrium and recombination analyses only limited genetic recombination, which occurred exclusively within the 60-kDa glycoprotein gene subtype IbA10G2, a predominant subtype for outbreaks in industrialized nations and a virulent subtype in the study community. Intensive transmission of virulent subtype IbA10G2 in the study area might have resulted in genetic recombination with other subtypes. Moreover, we identified selection for IbA10G2 at a 129-kb region around the 60-kDa glycoprotein gene in chromosome 6. These findings improve our understanding of the origin and evolution of C. hominis subtypes and the spread of virulent subtypes.
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