ArticleJournal of the American Chemical Society2013
Modulation of CEST images in vivo by T1 relaxation: a new approach in the design of responsive PARACEST agents.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- LnDOTA puppeteering: removing the water molecule and imposing tetragonal symmetry.Chemical science · 2023Article
- New anti-cancer explorations based on metal ions.Journal of nanobiotechnology · 2022Review
- Lanthanide Complexes (GdChemistry, an Asian journal · 2022Article
- New advances on Au-magnetic organic hybrid core-shells in MRI, CT imaging, and drug delivery.RSC advances · 2021Review
- Chemistry of MRI Contrast Agents: Current Challenges and New Frontiers.Chemical reviews · 2019Review
- Nitroxyl Modified Tobacco Mosaic Virus as a Metal-Free High-Relaxivity MRI and EPR Active Superoxide Sensor.Molecular pharmaceutics · 2018Article
- Imaging short-lived reactive oxygen species (ROS) with endogenous contrast MRI.Journal of magnetic resonance imaging : JMRI · 2018Article
- Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors.ACS central science · 2017Article
- The Role of Coordination Environment and pH in Tuning the Oxidation Rate of Europium(II).Chemistry (Weinheim an der Bergstrasse, Germany) · 2017Article
- Spectroscopic Characterization of the 3+ and 2+ Oxidation States of Europium in a Macrocyclic Tetraglycinate Complex.Inorganic chemistry · 2016Article
- A pH-Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window.Angewandte Chemie (International ed. in English) · 2015Article
- Overcoming the concentration-dependence of responsive probes for magnetic resonance imaging.Metallomics : integrated biometal science · 2015Review
- Oxidation-responsive Eu(2+/3+)-liposomal contrast agent for dual-mode magnetic resonance imaging.Chemical communications (Cambridge, England) · 2014Article
- Structure-redox-relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes.Inorganic chemistry · 2014Article
- Enhancing magnetic resonance imaging with contrast agents for ultra-high field strengths.The Analyst · 2014Review
- Redox- and hypoxia-responsive MRI contrast agents.ChemMedChem · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
A novel approach for the design of responsive paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) agents has been developed where the signal is "turned on" by altering the longitudinal relaxation time (T1) of bulk water protons. To demonstrate this approach, a model Eu(DOTA-tetraamide) complex (DOTA = 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) containing two nitroxide free radical units was synthesized. The nitroxide groups substantially shortened the T1 of the bulk water protons which, in turn, resulted in quenching of the CEST signal. Reduction of paramagnetic nitroxide moieties to a diamagnetic species resulted in the appearance of CEST. The modulation of CEST by T1 relaxation provides a new platform for designing biologically responsive MRI agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.