Evidence map›Paper›PMID 24050173›Full record

ArticleGenome medicine2013

The emergence of commercial genomics: analysis of the rise of a biotechnology subsector during the Human Genome Project, 1990 to 2004.

Ilse R Wiechers, Noah C Perin, Robert Cook-Deegan

Abstract read
In one paragraph

Article in Genome medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Current landscape and future directions of synthetic biology in South America.Frontiers in bioengineering and biotechnology · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ilse R WiechersCenter for Public Genomics, Institute for Genome Sciences & Policy, Duke University, Box 90141, Durham, NC 27708, USA ; Robert Wood Johnson Foundation Clinical Scholars Program, Yale School of Medicine and US Department of Veterans Affairs, 333 Cedar Street, PO Box 208088, New Haven, CT 06520-8088, USA.
Noah C PerinCenter for Public Genomics, Institute for Genome Sciences & Policy, Duke University, Box 90141, Durham, NC 27708, USA.
Robert Cook-DeeganCenter for Public Genomics, Institute for Genome Sciences & Policy, Duke University, Box 90141, Durham, NC 27708, USA ; Sanford School of Public Policy, Duke University, Box 90239, Durham, NC 27708, USA.

Funding

The Management and Organization Core will be administered by the Center for GenomP50HG003391 · NHGRI · DUKE UNIVERSITY · PI COOK-DEEGAN, ROBERT MULLAN · 2004 to 2014
$9.9M
NHGRI NIH HHS P50 HG003391
6 · The paper itself

Abstract

backgroundDevelopment of the commercial genomics sector within the biotechnology industry relied heavily on the scientific commons, public funding, and technology transfer between academic and industrial research. This study tracks financial and intellectual property data on genomics firms from 1990 through 2004, thus following these firms as they emerged in the era of the Human Genome Project and through the 2000 to 2001 market bubble.

methodsA database was created based on an early survey of genomics firms, which was expanded using three web-based biotechnology services, scientific journals, and biotechnology trade and technical publications. Financial data for publicly traded firms was collected through the use of four databases specializing in firm financials. Patent searches were conducted using firm names in the US Patent and Trademark Office website search engine and the DNA Patent Database.

resultsA biotechnology subsector of genomics firms emerged in parallel to the publicly funded Human Genome Project. Trends among top firms show that hiring, capital improvement, and research and development expenditures continued to grow after a 2000 to 2001 bubble. The majority of firms are small businesses with great diversity in type of research and development, products, and services provided. Over half the public firms holding patents have the majority of their intellectual property portfolio in DNA-based patents.

conclusionsThese data allow estimates of investment, research and development expenditures, and jobs that paralleled the rise of genomics as a sector within biotechnology between 1990 and 2004.

Identifiers

PMID24050173
PMCPMC3971346

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.